The Machine identifies a school teacher who witnessed a mob hit as their next POI and Reese and Finch rush to save his life.

Finch gives Reese his birthday off so that his partner doesn't have to face a Number that is tied to Reese's past.

The Machine gives Finch and Reese the number of a brilliant surgeon, but they soon discover that a resourceful third party has raised the stakes for this POI, forcing them to turn to an unlikely source for help.

As Reese and Finch try to save a hotel maid's life, they encounter a litany of suspects; Detective Carter considers a significant offer from the FBI.

The number comes up for an Internet entrepreneur in the business of eliminating people's privacy, but finds his own being rapidly stripped away. As his life spirals out of control, Reese tries to protect him while Finch calls on Shaw, Carter and Fusco for help finding whoever is after him.

The battle to bring a crime organization to justice reaches a new level; Reese's number comes up in the machine.

As Decima uses Samaritan’s feeds to hunt Reese and Shaw, Greer exploits Finch’s greatest weakness in an attempt to lure him out of hiding: his love for his former fiancée, Grace Hendricks.

Finch recruits Fusco to stick close to the latest POI, a professional 'wingman', but learning how to approach women soon becomes the least of his worries. Reese must find a way to play by the rules at his new day job. The Machine sends Finch and Root on a mysterious errand.

Reese and Finch must protect Harper, a street-smart grifter, when her plan to steal cash from a medical marijuana dispensary goes up in smoke.

Reese and Fusco get caught in the war between the two newest POIs, rival crime bosses Elias and Dominic. Also, a tantalizing clue to Shaw’s whereabouts leads Finch and Root into a possible trap, and Control goes rogue to uncover the true intentions of the Samaritan program.

Finch’s number comes up when a fatal error blows his cover identity and sets off a deadly series of escalating encounters with Samaritan’s operatives.