The team takes on the case of a high school senior who inexplicably blacks out during a class field trip. While in the hospital, the patient repeatedly hallucinates. After exhausting myriad ineffective treatments for her mysterious ailments, House attempts one last controversial approach to diagnosing her: monitoring her cognitive patterns and looking for clues. Meanwhile, Taub airs his dirty laundry at work, and Wilson attempts to furnish his condo.

During a session with Dr. Nolan, House recounts the case of a woman who arrives at the Princeton Plainsboro emergency room with an unexplained illness and no recollection of who she is. While trying to solve the mystery of the woman's illness, House must also help her piece together her identity.

It’s election season, and in the midst of a tight campaign, an incumbent New Jersey senator’s campaign manager falls ill with liver failure and temporary paralysis. Cuddy pushes House to add a female doctor to his team by hiring brilliant third-year medical student Martha Masters in Thirteen’s absence.

House and the team try to link symptoms of a teenage military recruit and his drill sergeant, while House secretly helps Cuddy's daughter get into a prestigious preschool. Someone posted a disparaging photo of Chase on a social-networking site.

Cuddy’s mother, Arlene, is admitted to Princeton Plansboro after complaining about unusual symptoms, but stubborn Arlene insists that House be removed from the case, forcing House to come up with non-conventional means to treat his patient.

House participates in a school’s Career Day and breaks a few rules by sharing explicit medical stories. Waiting outside the principal’s office, he meets two fifth-grade students who assess House’s relationship woes and try to help him understand how his selfish antics get in the way of showing Cuddy how he really feels.

A patient is admitted after breaking out in a severe rash triggered by caustic chemical exposure at his blue-collar job. Meanwhile, Cuddy is honored with an award and needs House to be at the charity event for support, but his attendance is threatened when his patient’s battle to survive forces him to question his practice and his own happiness.

When a runaway teen requires hospitalization, Adams butts heads with House when she insists they contact Social Services. Meanwhile, Taub has trouble forming a personal connection with his baby daughters and Foreman's relationship with a married woman comes out.

Chase's religious faith bubbles to the surface when he treats a young nun. In addition, he and House reach a fundamental disagreement about the patient that may finally end Chase's reputation as House's "yes man" but also bring's House's methods, reputation and objectivity are given more serious scrutiny.

House and the team take on the case of a young boy who has violent dreams of being choked, and then wakes up but still can't take in air. Meanwhile, Park is having intimate dreams involving co-workers, which causes the team to question whether or not there's significance to what each of them dreams. Dominika discovers House has been keeping a secret from her and Wilson drops a bombshell on him.

Over the years, during the course of performing autopsies at Princeton-Plainsboro, Dr. Peter Treiber has often identified mistakes made by physicians that caused the patient's death. These observations have left him questioning the skills of nearly all the doctors on staff... all, that is, except House. When he falls ill, he demands that only House make medical decisions concerning his care. Unfortunately, House and Wilson have taken off on an impromptu road trip without telling anyone, leaving the team to fend alone and lie to their patient to make him believe that House is the guy calling all the shots.

The team takes on the case of Derrick, a 19-year-old college student who had a mysterious nose bleed during cheerleading practice, and discovers that his health issues are likely both physiological and psychological. Possibly suffering from schizophrenia, Derrick claims to hear his deceased brother’s voice in his head. Meanwhile, Foreman tries a different approach with House.