A Cuban couple attempt to get to America by raft... to see House about the wife's heart condition. But when she gets worse House wonders if someone on his staff messed up. Meanwhile Foreman prepares to leave and his departure threatens to shake up the entire team.

Charlotte, an older woman who has spent the last six months taking care of her dying husband Eddie, is rushed to Princeton Plainsboro after collapsing from respiratory failure. The couple becomes a double mystery for the team when Eddie begins to improve as Charlotte’s condition worsens. The previously unthinkable becomes real when it seems that Charlotte will die before Eddie, and the team will be forced to make a difficult decision.

A wealthy businessman brings his teenage son, who is suffering from inexplicable stomach pains, to Princeton Plainsboro and insists on having Dr. House handle the case. The father of the patient believes the karmic penalty of his financial success is that he is victim to personal tragedy, and that the answer to his son's medical mystery lies in a reverse of fate rather than medical treatment. Meanwhile, Foreman and Chase prepare to present information on the Dibala case.

During a day in the life of Princeton Plainsboro's Dean of Medicine, Dr. Lisa Cuddy, the inner workings of the hospital are seen through her eyes. This day proves to be especially trying as Cuddy wrestles with myriad hospital issues and staff disputes that test her perseverance and skills as an administrator, all while juggling issues in her personal life.

House and the team take on the case of a woman Julia, who is in an open marriage and becomes ill during a date with her on-the-side boyfriend. As perplexing as the case is, Julia's happy and healthy, yet polygamous relationship is equally baffling to the team. Meanwhile, House tests Wilson's relationship with Sam.

Napätie dosiahne nových výšok, keď je Cuddy postavená pred správu nútiaca k zamysleniu, ktorá ju postrčí k prehodnoteniu svojich priorít. Kým House je rozptýlený obavami o Cuddyino zdravie, tím lieči mladistvého pacienta, ktorého zhoršujúce sa symptómy a podozrivé jazvy na tele naznačujú niečo viac než len fyzické ochorenia. Taub, ktorý vytuší nešťastný emocionálny a duševný stav mladíka, sa vydá hľadať vodítka v pacientovom osobnom živote a objaví znepokojivú domácu nahrávku, ktorá by mohla život jeho rovesníkov ohroziť. Medzitým Cuddy stále pevne dúfa, že House tu pre ňu bude, keď ho bude najviac potrebovať, a rad snov, vrátane muzikálovej scény s choreografiou od Mia Michaels, poskytnúť jej letmý pohľad do jej života a jej vzťahu s Housom.

Mladý šampión v zápase s býkmi je hospitalizovaný potom, čo bol kompenzovať jedným z nich. Po vykonaní nespočetných neprůkazných testov sa tím obráti na House, ktorý je mimo nemocnici a venuje sa pár záležitostiam mimo prípad. Späť v nemocnici sa stav toreadora zhoršuje, ale s mizícími symptómy a frekventovanějšími malými záchvaty sa tím rozhodne k riskantné operáciu s otvoreným srdcom. A Masters sa k Taubovu prekvapenie do mladého toreadora zamiluje.

Lekársky tím sleduje cez skrytú kameru umelecké vystúpenia ženy trpiace údajne neznámou chorobou. Žena si s nimi vlastne celý čas hrá a niektoré príznaky svojej choroby predstiera, aby lekára schválne zmiatla. Predovšetkým pre House je jej počínanie veľká výzva a postupne nadobúda presvedčenie, že žena má rakovinu.

A prosecutor suffers from what he believes to be cardiac arrest during an interrogation at the witness stand. The team's preliminary diagnosis is hyper-anxiety, but when Adams and Park investigate the patient's home and find a hidden arsenal of firearms, they uncover a more alarming and deep-seated psychological disorder.

House and his team are placed under review after a staff member gets hurt.

Chase's religious faith bubbles to the surface when he treats a young nun. In addition, he and House reach a fundamental disagreement about the patient that may finally end Chase's reputation as House's "yes man" but also bring's House's methods, reputation and objectivity are given more serious scrutiny.