Dr. House's young patient believes his illness is the result of a curse while House uncovers important information about Chase's father.

A young mother has a seizure while bathing her newborn son and nearly drowns him. House and the team have two cases at one time as they try to save the infant and determine the cause of the mother's seizures.

House and the team treat a young boy who claims there is a tracking device in his neck and believes he has been the subject of alien experimentation. Cameron is outraged when she learns Cuddy and Wilson have been lying to House about the diagnosis on his last case.

An 18-year-old teenager is brought to the hospital after having a heart attack. House reviews the boy's file and believes he has the diagnosis. He then turns the case into a game by sealing his opinion in an envelope and challenging Cameron, Foreman, and Chase to guess House's diagnosis on their own. Meanwhile, Tritter's actions against Wilson continue to strain the oncologist's relationship with House and destroy his ability to practice medicine.

House splits his time between treating a firefighter for uncontrollable shivering, giving Tritter a piece of his mind, and handling his trial for forging prescriptions.

A 6-year-old girl suffers ailments expected in patients much older. Tensions between Chase and Cameron lead House to intentionally assign them to the same tasks, including investigating the young girl's home.

House treats a 16-year-old chess prodigy who gets everyone on the team annoyed with his behavior. Foreman is upset with House because he thinks his boss sabotaged his job interview with another hospital.