Dr. Gregory House, a brilliant diagnostician but devoid of bedside manner, and his elite team of young medical experts rush to save the life of a kindergarten teacher who started speaking gibberish and passed out in front of her class.

Dr. House and his team race to save a young man who may have not one, but two illnesses killing him.

A baseball player's comeback is cut short when he breaks his arm and House and his team have to act fast to figure out what is causing major bone loss that's killing the player and his dreams.

House and his team battle to diagnose a pregnant patient's life-threatening illness, prompting her to make the most emotional decision of her life, and Vogler is determined to fire House.

House must decide whether to take the case of his ex-love's husband and he gives medical students a lecture they'll never forget.

Foreman continues to experience the same progression of symptoms as the police officer. When he realizes he may be facing imminent death, he calls his father who comes to his son's side. As it comes down to a race against time, House believes the solution to the illness is in the police officer's apartment.

House is shot by a former patient and must share a recovery room with the gunman.

After recovering from his gunshot wounds, House works feverishly on two cases at the same time: a paralyzed man who drove his wheelchair into a swimming pool and a woman who became paralyzed after a yoga session.

House and the team treat a young boy who claims there is a tracking device in his neck and believes he has been the subject of alien experimentation. Cameron is outraged when she learns Cuddy and Wilson have been lying to House about the diagnosis on his last case.

While House is forced to work full-time in the clinic and deal with a rape victim who insists on confiding with him, Cameron deals with a terminal cancer patient trying to take advantage of her state of mind.

With his diagnostic team gone, House tries to diagnose a young woman who survived an office building collapse. With the condition getting worse, Cuddy puts pressure on House to hire a new team, but instead attempts a differential diagnosis with help from the janitor.

House copes with a patient whose symptoms conceal a greater problem, but spends much of his time dodging Cuddy's orders to give performance reviews, and fighting with Amber over who gets to spend more time with Wilson.

The team deals with an organ donor whose organs prove fatal, and the two surviving patients. Meanwhile, House hires a private detective to spy on Wilson, but hears a few things about himself that he'd rather not.

House engages in a battle of wits and wills against the attending physician in charge of his detox program. When he starts to lose, House resorts to blackmail to gain the upper hand.

House and Park treat a patient, Benjamin, who collapsed after making a surprisingly large charity donation, and come to suspect that the altruistic behavior is a symptom of a deeper disorder. When the patient offers to donate an organ for another patient, the doctors must convince Dr. Adams to help them confirm whether Benjamin is in his right mind or not.

The team learns that their 14-year-old patient is suffering from more than teen angst when her physical symptoms worsen. Despite Foreman’s firm opposition, House becomes obsessed with solving a peculiar case of a deceased four-year-old patient, which gets him into serious trouble. Meanwhile, Park tries to get Chase to admit the reason behind his recent obsession with grooming.

House and the team take on the case of a young boy who has violent dreams of being choked, and then wakes up but still can't take in air. Meanwhile, Park is having intimate dreams involving co-workers, which causes the team to question whether or not there's significance to what each of them dreams. Dominika discovers House has been keeping a secret from her and Wilson drops a bombshell on him.

Facing a 6-month jail term, and the realization that he won't be there for Wilson at the end, House finds himself examining his entire life while contemplating a dismal future without his best friend.