In the aftermath of the events chronicled in the feature film Marvel's Thor: The Dark World, Coulson and the agents of S.H.I.E.L.D. pick up the pieces–one of which threatens to destroy a member of the team.

S.H.I.E.L.D. organizes a full scale hunt for Coulson. Meanwhile, Coulson uncovers vital information about the mystery of his death, but, with Centipede out for blood, this knowledge may come at the cost of one of the team!