Coulson and his team are haunted by a ghost that threatens to destroy them all, and only a secret from May's past can save them.

Daisy has left S.H.I.E.L.D. and is trying to solve the mystery of a bunch of serial killings in the Los Angeles area. At the same time her old friends suspect her for the killings and are following her trail in an attempt to find her.

As Robbie Reyes struggles to control the Ghost Rider; S.H.I.E.L.D. infiltrates a high-security prison to unravel the secrets that haunt them all.

Robbie's shocking story on how he became Ghost Rider is finally discovered as Coulson and his team's lives hang in the balance.

With the loss of half the team, the remaining members search for answers as the clock counts down for Ghost Rider.

Separated from their team, Coulson and Mack discover a shocking secret about Mace, leaving all of S.H.I.E.L.D. in a precarious position.

Agents Sam and Billy Koenig are hunted down to get at the Darkhold book, and only Phil Coulson and the team can save them before the clock ticks out.

Daisy, Director Mace and the S.H.I.E.L.D. team must find a way to contain an explosive Inhuman. Meanwhile, Coulson and Mack come face-to-face with Radcliffe’s inspiration for Aida.

Mace fights for his life while Coulson and team find themselves in a deadly cat-and-mouse game as they attempt his rescue.

Suspicion turns to paranoia when the team doesn't know who can be trusted as more LMDs infiltrate S.H.I.E.L.D.

The clock is ticking for Daisy and Simmons to get the team out of the Framework, but not everyone is ready and willing to leave.

Coulson and the team's victory in the Framework is short-lived, as an even deadlier enemy looms against them all.

In the milestone 100th episode, Coulson finally reveals the mysterious deal he made with Ghost Rider, which will impact everyone on the team.

The team goes in search of Gravitonium in order to save the world.

Coulson is forced to team up with surprising allies to save the world, while the S.H.I.E.L.D. team attempts to track down and rescue him.

While an agent's life hangs in the balance, Fitz, Simmons, and Yo-Yo attempt to neutralize a weapon that could play a role in Earth’s destruction.

Coulson and the team find themselves under siege at the Lighthouse.

A newly determined Talbot takes Coulson to meet the enemy and attempts to avert Earth's destruction.

Daisy's future as the Destroyer of Worlds could take a critical change.

Coulson's life or death is the challenge the team finds themselves in, as the wrong decision will cause the Destruction of Earth.

Scattered across the galaxy, the team works to find their footing in the wake of losing Coulson.

It’s a wild night out on the planet of Kitson for the agents. While Leo and Enoch try their luck at the casino, nearby, Daisy and Simmons find themselves in a much... groovier situation.

Sarge has May; Atarah has Daisy, Enoch and Simmons; and now, there are two planets that need saving.

To face The Galaxy-Hopping Hate-Beast That Eats Planets, the team on Earth asks for help in all the wrong places. While back on the Lazy Comet, something weird is going on with Izel’s crew, and it’s not just the puffies.

No time for the team to play catch-up, there's a planet to save.

The party’s over, and now the team must trust each other in order to face impending doom and an enemy that’s closer than they think.

With their backs against the wall and Nathaniel and Sibyl edging ever closer to eliminating S.H.I.E.L.D. from the history books, the agents must rely on their strengths to outsmart and outlast the Chronicoms. This is their most important fight, and it will take the help of friends and teammates, past and present, to survive.