As Coulson, Mack and Fitz attempt to track down and neutralize a rogue group looking to end Inhuman Registration worldwide, Simmons and Dr. Radcliffe only have hours to save May before she succumbs forever to her mysterious illness.

As Robbie Reyes struggles to control the Ghost Rider; S.H.I.E.L.D. infiltrates a high-security prison to unravel the secrets that haunt them all.

Coulson is unaware of a dark secret May is hiding, even as the two grow closer; Aida is determined to find the Darkhold.

May works to uncover the truth about what happened to her; Aida's next move puts everyone's life at risk.

Daisy, Director Mace and the S.H.I.E.L.D. team must find a way to contain an explosive Inhuman. Meanwhile, Coulson and Mack come face-to-face with Radcliffe’s inspiration for Aida.