Cal seeks revenge on Coulson by assembling a team of Super Villains to destroy S.H.I.E.L.D. Meanwhile, May calls on renowned Dr. Andrew Garner, her charismatic ex-husband, with a crisis that threatens to tear the team apart.

The story of Melinda May’s transformation into “The Cavalry” is revealed as she finds herself at a crossroads in the war between Coulson and Gonzales. As Skye learns more about her true heritage from Lincoln, the truth about the Inhumans will send her in a new direction.

S.H.I.E.L.D. puts everything on the line to survive a war that blurs the line between friend and foe. Coulson and his team will be forced to make shocking sacrifices that will leave their relationships and their world changed forever.

Fitz and the team enlist the aid of an Asgardian to unlock the secrets of the ancient Monolith that swallowed Simmons, and Agent May is at a crossroads in her personal and professional life.

Coulson and the team search for the Inhuman who is killing other Inhumans. Meanwhile, May feels that Hunter's mission to take down Ward is getting too personal.

The stakes get even higher as Hunter and May continue to go after Ward and HYDRA, and Daisy and Coulson begin to suspect that the ATCU may be keeping a big secret from S.H.I.E.L.D.

As Daisy and the team fight to protect Inhumans, S.H.I.E.L.D. discovers the shocking truth about one of their foes; Fitz helps Simmons recover information that could lead them back through the portal.

The S.H.I.E.L.D. team discovers dangerous truths about the ATCU, and Ward's plans to destroy S.H.I.E.L.D. take a surprising twist.

A battle between HYDRA and S.H.I.E.L.D. will change Coulson's world; Fitz and Coulson take a huge risk.

When Daisy gets a horrifying glimpse of the future, S.H.I.E.L.D. races to prove that fate is not fixed.