An elusive girl in a flower dress may hold the key to the mystery that brings Coulson and team to Asia to rescue a young man with an unusual and dangerous power; and Skye has a secret that jeopardizes her relationship with the team right when they need her most.

Hunted and running out of solutions, Phil Coulson puts his team right in the line of fire in the hopes of saving them all. But with General Glenn Talbot, HYDRA, and Carl Creel all on the attack, can they possibly survive? Meanwhile, a mysterious Doctor harbors some dangerous secrets that could destroy one of our core team members.

Coulson and his team are still reeling from a shocking revelation that leaves the team fractured as they must decide what to do with one of their own. Meanwhile, Bobbi and Mack reveal their true allegiance to Hunter, while elsewhere, Ward and Agent 33 embark on a personal mission.

After her dramatic rescue from another planet, Simmons is still reeling from her ordeal and reveals how she had to fight for her life in a harsh new world.

When a radical group called The Watchdogs emerges with plans to eliminate the Inhumans, Agent Mack and his brother become caught in the crossfire. Meanwhile, Simmons discovers a powerful chemical compound that could alter the future for Inhumans.

With the loss of half the team, the remaining members search for answers as the clock counts down for Ghost Rider.

May works to uncover the truth about what happened to her; Aida's next move puts everyone's life at risk.

Coulson and the team find themselves stranded on a mysterious ship in outer space, and that's just the beginning of the nightmare to come.

With the surprising help of Lance Hunter, nothing will stop Fitz from finding the lost team as his incredible journey is revealed.

Coulson uncovers General Hale's true agenda, and it could be the end of the world if S.H.I.E.L.D. doesn't help her.

It’s a wild night out on the planet of Kitson for the agents. While Leo and Enoch try their luck at the casino, nearby, Daisy and Simmons find themselves in a much... groovier situation.

They've fought through space, time and alternate realities to find each other, and now, closer than ever, only their own demons can stop FitzSimmons' reunion.

After being unexpectedly stranded in 1982, Mack retreats to his childhood home to process the death of his parents, while Deke gets to work scouting a chart-topping group of new agents. With no idea if or when the team is coming back for them, time seems to finally be on their side … at least until the killer robots show up.