În urma bătăliei The Răzbunători din New York, lumea încearcă să prindă prezența supereroilor, zeilor și extratereștrilor în mijlocul lor. Agentul Coulson este înviat în circumstanțe misterioase și formează o echipă de elită de agenți din S.H.I.E.L.D. pentru a urmări o organizație secretă cunoscută sub numele de The Rising Tide. Între timp, trebuie să se ocupe de alte amenințări, cum ar fi un om care se găsește brusc cu o mare putere incontrolabilă.

Coulson and his S.H.I.E.L.D. agents travel to Peru to investigate an object of unknown origin, codenamed 0-8-4. But when he runs into Comandante Camilla Reyes, more than just sparks fly at 30,000 feet.

When the brilliant scientist, Dr. Franklin Hall, is kidnapped, Agent Coulson and his S.H.I.E.L.D. agents must race against the clock to locate him. Skye is their only way in–pushing the team to their limits when the entire plan turns upside-down.

Coulson and his team are haunted by a ghost that threatens to destroy them all, and only a secret from May's past can save them.

Coulson and May uncover startling information about Skye's past, while the team is swept into a storm at a S.H.I.E.L.D. Academy of Science and Technology.

Coulson and his team find themselves without anyone they can trust, only to discover that they are trapped with a traitor in their midst.

Dark secrets are revealed as Coulson and his team put everything on the line to stop Garrett and the forces of HYDRA.

Coulson and his team are now wanted fugitives with limited resources, but that's not stopping them from keeping the world safe from powerful and unseen threats everywhere. However, with new members they hardly know, will S.H.I.E.L.D. ever be trusted again?

Coulson's team must deal with the consequences of their war with HYDRA as shocking revelations threaten to tear them apart, and HYDRA makes a dangerous move that may involve a traitor in S.H.I.E.L.D.'s midst.

S.H.I.E.L.D. puts everything on the line to survive a war that blurs the line between friend and foe. Coulson and his team will be forced to make shocking sacrifices that will leave their relationships and their world changed forever.

When a new Inhuman is discovered, Coulson and the team have an encounter with another organization seeking powered people; Fitz goes to extreme measures to determine how to get Simmons back.

Bobbi and Hunter become ensnared in an assassination plot after tracking Malick to Russia. As S.H.I.E.L.D. races to save the lives on the line, the team is changed forever.

When Daisy gets a horrifying glimpse of the future, S.H.I.E.L.D. races to prove that fate is not fixed.

It's a showdown a season in the making as S.H.I.E.L.D. takes on Hive, and when his master plan is finally revealed, the team must spring into action. Who will live and who will die?

Daisy has left S.H.I.E.L.D. and is trying to solve the mystery of a bunch of serial killings in the Los Angeles area. At the same time her old friends suspect her for the killings and are following her trail in an attempt to find her.

Suspicion turns to paranoia when the team doesn't know who can be trusted as more LMDs infiltrate S.H.I.E.L.D.

Coulson and the team's victory in the Framework is short-lived, as an even deadlier enemy looms against them all.

Coulson and the team find themselves stranded on a mysterious ship in outer space, and that's just the beginning of the nightmare to come.

In the milestone 100th episode, Coulson finally reveals the mysterious deal he made with Ghost Rider, which will impact everyone on the team.

Coulson's life or death is the challenge the team finds themselves in, as the wrong decision will cause the Destruction of Earth.

Scattered across the galaxy, the team works to find their footing in the wake of losing Coulson.

Who will survive? It all comes down to this.

After Enoch’s sacrifice propelled them out of the time storm, the team arrives back in 1983 where Nathaniel and Kora are hard at work building an army of hand-selected anarchist Inhumans at Afterlife. When the agents split up to cover more ground, Daisy is tasked with protecting Jiaying and is compelled to confront her mother for the first time since her death; while the others quickly learn they’ll need to face yet another supercharged former enemy in order to stop Malick.

With their backs against the wall and Nathaniel and Sibyl edging ever closer to eliminating S.H.I.E.L.D. from the history books, the agents must rely on their strengths to outsmart and outlast the Chronicoms. This is their most important fight, and it will take the help of friends and teammates, past and present, to survive.