IMDB plot synopsis has this to day about the second to last ep:
"In the aftermath of an overwhelming loss, the communities must brave a ferocious blizzard; as one group deals with an enemy from within, another is forced to make a life or death decision."
My money is on Michonne . The actress is slated to leave mid season 10 but seeing they did that twice this year, maybe the producers decided to knock her off in this season? I doubt we'll lose Daryl; but I suppose the King, Henry, Carol, or Inid would be considered an overwhelming loss, too. Still, Michonne tops my guess list due to the aforementioned planned exit.
OR the big loss could be the Whisperers follow the trail to the festival and attack; leaving a bunch of extras dead...
Enemy from within? The Highwaymen of course. Or Lidia if Daryl decides to take her to Alexandria... Or good old Negan!
Life or death?? Who knows when everything is life or death.
Next week sounds like the ultimate filler. A flashback to how Daryl and Michonne got their scars. I do not care.