Uncle Junior's associate Mikey Palmice stirs things up by making Junior think Tony wants to be next in line for boss. Meanwhile, Tony, Paulie and Silvio deal with Hasidic family problems.

Jackie Aprile's health worsens, forcing Tony to make a tough decision. Meanwhile, Anthony Jr. learns the true nature of his father's job in 'waste management.' Also, Tony hires sleazy police lieutenant Vin Makazian to investigate Dr. Melfi's background.

During a trip to Maine for Meadow's college interviews, Tony sees a man he believes is a relocated mob snitch. Back at home, Carmela receives comfort from Father Phil.

At Tony's suggestion, Junior is made acting boss after Jackie dies. In therapy, Tony surprises Dr. Melfi with an admission. Carmela and Irina (Tony's mistress) both suffer as Tony's libido takes a nosedive.

Christopher and Adrianna cut a deal with a famous gangsta rapper who claims that Hesh pocketed royalties belonging to a cousin who recorded several hit songs decades ago. Meanwhile, Tony plays golf with Cusamano and his white-bread friends.

Season Two opens with the aftermath of the federal crackdown: Junior's in jail, Melfi refuses to see Tony, Christopher's expanding into new business ventures, Pussy is still missing...and Tony's adjusting to life as the new boss. To complicate matters even more, Tony's free-spirited sister Janice arrives to take care of Livia.

Back in Jersey, Furio soon lives up to his name by unleashing his fury on the delinquent proprietor of a local 'tanning salon.' Dr. Melfi shares her guilt over dumping Tony as a client during a session with her own therapist. Meanwhile, Tony learns from Hesh that his father had emotional secrets of his own.

Engaged lovebirds Richie and Janice have an explosive first quarrel. Meanwhile, Irina takes drastic measures to try to convince Tony to continue their affair.

Christopher finds that being a 'made' man isn't all it's cracked up to be. Meanwhile, Janice moves into her mother's house, where she soon gets a leg up on Livia's former housekeeper.

Dr. Melfi's attempts to steer Tony into behavior-modification therapy take a detour when a personal crisis gets in the way. Meanwhile, Ralph Cifaretto finds a way to endear himself to Jackie Jr.--but not to Tony.

Paulie and Christopher are engulfed in a nightmarish journey into the South Jersey woods while trying to collect a debt from a Russian mobster. Meanwhile, Meadow is suspicious that Jackie Jr. is two-timing her, and Tony finds that family demands are jeopardizing his romance with Gloria.

Tony and the gang throw Paulie a Bada Bing bash after his release from jail, but it doesn't take long for old tensions to resurface. Carmela's cousin Brian throws out a hypothetical investment scenario that Tony and Ralph attempt to turn into reality with the help of Assemblyman Zellman and a black community leader.

In the Season Four finale, Tony and Carmela contemplate purchasing a shore house, but a voice from the past threatens the deal. While Uncle Junior breaks out the Hearty Burgundy, Little Paulie and Benny break in a new sound system on the Stugots. With Carmine apparently intent on putting the past behind him, Tony and Johnny Sack weigh their options, carefully.