After suffering a series of mysterious anxiety attacks, New Jersey mob boss Tony Soprano agrees to see a psychiatrist, Dr. Jennifer Melfi. As he opens up to the doctor, Tony reveals details about his problems at home and at work that involve his wife Carmela, his kids Meadow and Anthony Jr., his Uncle Junior and his domineering mother Livia.

Having dodged a legal bullet, Tony is advised by his lawyer to spend more time at his businesses. Junior looks for diversions to relieve the tedium of house arrest, and eventually finds one in the company of a police widow. Meanwhile, Melfi's problems boil over while eating dinner with her son.

Engaged lovebirds Richie and Janice have an explosive first quarrel. Meanwhile, Irina takes drastic measures to try to convince Tony to continue their affair.