Tony Soprano, o chefe da máfia de Nova Jersey, começa as sessões de terapia com a dra. Jennifer Melfi após ter sofrido ataques de pânico. Sua mãe, Livia, recusa-se a ir para um asilo. Seu tio quer usar o restaurante dos amigos de Tony para cometer um assassinato, mas Tony evita o crime explodindo o restaurante. Christopher Moltisanti, o sobrinho de Tony, extermina o porta-voz da máfia tcheca que estava tentando infiltrar-se nos negócios da família.

Christopher e Brendan Filone começam a roubar caminhões. Eles descobrem que o proprietário dos caminhões paga Junior por proteção, mas o vício em drogas de Chris e Brendan os impede de respeitar as ordens de Junior. Carmela pede a Tony um favor que envolve o carro roubado da professora de ciências de A.J.. Após vários incidentes, Tony força Livia a se mudar para um asilo, mesmo contra a vontade dela.

Os Sopranos contratam os Buccos para prepararem um jantar. A filha de Tony, Meadow, pede a Christopher e Brendan algo que a deixe acordada para preparar-se para os exames do SAT. Tony aceita a tarefa de assegurar o divórcio da filha de um judeu hassídico. Junior libera a retribuição a Christopher e Brendan pelo roubo dos caminhões.

Tony pede ao seu amigo, o detetive Vin Makazian, para seguir a dr. Melfi depois que ela apareceu em seus sonhos. Christopher pede vingança contra Junior e Mikey Palmice pela morte de Brendan. Surge a dúvida sobre quem será o sucessor de Jackie Aprile.

Tony e Meadow viajam para Maine para conhecer as faculdades, e eles discutem a natureza do "negócio" de Tony. Carmela luta contra uma gripe e busca conforto com Padre Intintola após descobrir que o terapeuta secreto de Tony é uma mulher. Tony encontra um antigo sócio que associou-se ao Programa de Proteção a Testemunhas e segue-o por "questões de negócios".

Tio Junior é escolhido como o chefe da família DiMeo. Tony esquematiza uma maneira de convencer Junior a perdoar seu amigo judeu. O aniversário de 18 anos de casamento de Carmela e Tony vai de mal a pior. O Prozac que a dr. Melfi receitou a Tony começa a afetar sua libido apesar de seus sonhos recorrentes o levarem a se apaixonar por sua terapeuta.

A.J. e seus amigos roubam o vinho da igreja e chegam bêbados para a aula de educação física. Tony não dá importância ao incidente até que o psicólogo da escola alerta-o que A.J. pode ter Transtorno de Déficit de Atenção. Tony relembra episódios de sua infância na terapia. A.J. é castigado e tem que visitar sua avó, Livia, todos os dias durante as próximas três semanas.

A Família Lupertazzi esconde-se para evitar possíveis complicações com o FBI. Tony e seus parceiro, sem Christopher, são apontados como suspeitos em uma grande investigação. Christopher fica deprimido por sua exclusão, ele tem pesadelos e tentar encontrar um novo foco escrevendo um filme, sem sucesso. Livia recebe notícias que a deixam chocada e repassa as informações para Junior.

Os pais ficam chocados quando descobrem que um treinador do time do ensino médio cometeu um crime terrível. Os boatos sobre os segredos sexuais de Junior chegam aos ouvidos de Tony. Junior sente-se humilhado quando Tony faz referências a ele e a Roberta.

De acordo com as sugestões da dr. Melfi e Carmela, Tony tenta ser mais sociável e procura conhecer melhor seus vizinhos. Christopher e sua namorada Adriana La Cerva tornam-se amigos do mestre do rap, Massive Genius. Christopher concorda em ajudar Adriana a produzir o demo para uma banda, apesar de um de seus membros ser o ex-namorado de Adriana. Massive Genius ameaça processar Hesh por supostos royalties roubados.

Uma pista de Vin Makazian leva Tony a tomar uma decisão difícil a respeito de um de seus amigos mais confiáveis. Tony pede a Paulie Walnuts para tomar conta de tudo. Junior, Mikey e Chucky Signore, após uma conversa com Livia, armam uma conspiração para consolidar o poder.

Apesar da orientação do uso de Prozac e lithium pela dr. Melfi, Tony sofre de depressão crônica. Ele tem alucinações quando conhece Isabella, uma linda estudante de intercâmbio italiana que está hospedada na casa dos Cusamanos, o que temporariamente o deixa animado. O plano de Junior é colocado em ação. O FBI vai até a casa dos Sopranos.

Junior e Tony concordam sobre a situação com Jimmy Altieri. Tony descobre o plano de sua mãe e de seu tio. Ele avisa a dr. Melfi que a vida da terapeuta pode estar em perigo. Christopher, Paulie e Silvio Dante tomam conta dos negócios da família. O amigo de Tony, Artie Bucco, reabre seu restaurante.

A liderança de Tony em Nova Jersey é interrompida pela chegada de sua irmã mais velha, Janice, que tenta se reconciliar com a mãe deles. Pussy tem um retorno complicado à gangue de Tony.

Janice começa a fazer planos para quando sua mãe sair do hospital. Tio Junior pede para sair da cadeia. Um canteiro de obras torna-se o cenário de um protesto violento. Tony continua a consolidar suas aquisições.

Tony encara uma nova ameaça quando o irmão de Jackie, Richie Aprile, sai da cadeia e tenta dar palpites nas atitudes de Tony. Carmela e Tony tentam punir Meadow por destruir a casa de Livia durante uma festa. A culpa de Melfi por não tratar Tony começa a aparecer nos sonhos dela.

Tony, Christopher e Paulie fazem uma viagem de negócios até a Itália. Carmela pensa sobre sua situação quando a esposa de Pussy dá entrada no processo de divórcio. Pussy reage contra um velho amigo quando o flagra conversando com o FBI.

Christopher e Pussy ficam ressentidos quando Tony inventa uma nova hierarquia. Christopher tenta aliviar o estresse participando de aulas de interpretação, enquanto Pussy está cada vez mais próximo do FBI. Melfi finalmente diz a Tony que o aceita novamente como paciente.

Tony organiza um torneio de pôquer, mas deve ser rígido com um velho colega de escola quando ele perde tudo. Richie entra em confronto com Tony quando causa perturbações ao jogo. Janice começa a fazer a cabeça de Richie sobre jogos de poder.

Christopher se arrisca em Hollywood. Ele e Jon Favreau trocam idéias. A. J. destrói o carro de sua mãe. Tio Pussy luta com sua consciência quando se envolve mais com a polícia.

Carmela pressiona um amigo para que ele escreva uma carta de recomendação para Meadow. Uma boa ação que Richie faz para Tony cai por terra. Matt e Sean estão entediados com suas posições na hierarquia. Eles decidem fazer uma emboscada para Christopher como favor para Richie.

Tony começa a caçada por Matt e liga para Pussy, pedindo um favor. Paulie fica nervoso quando Christopher lhe traz notícias. Carmela pede para Tony fazer uma vasectomia. Melfi começa a se arrepender de aceitar Tony novamente em seu divã.

Tony começa a juntar dinheiro para uma possível fuga quando ele descobre que há testemunhas para o golpe a Bevilaqua. Os policiais aumentam a pressão sobre Pussy quando descobrem o seu envolvimento no assassinato. Richie tenta alistar Junior em um plano contra Tony. Carmela tem um encontro romântico.

O advogado de Tony o aconselha a agir como civil por enquanto, mas Tony fica entediado com esse estilo de vida. Melfi começa a beber para agüentar as sessões de Tony. Junior procura uma companhia feminina durante seu confinamento, enquanto Richie desobedece mais uma ordem de Tony.

Richie finalmente chega ao limite de Tony, que começa a planejar sua remoção. Tony descobre que romper com sua namorada russa é mais complicado do que ele poderia imaginar. Janice decide agir depois de uma discussão com Richie.

Tony sofre com intoxicação alimentar e sonha com uma estranha conversa com Pussy em seu delírio. Quando Tony acorda, suas suspeitas emergem. O FBI prende Livia no aeroporto com evidências que podem incriminar seu filho. Os policiais decidem tentar prender Tony logo antes da formatura de Meadow.

While the Soprano family goes about their day-to-day activities, the FBI begins an elaborate operation to bug their home. Tony ponders his options when Patsy starts asking too many questions about his brother's death.

Tony's concerns that his mother will rat him out to the feds expire when she, literally, does. Later, Janice arrives to arrange the funeral, which takes a bizarre turn.

Christopher finds that being a 'made' man isn't all it's cracked up to be. Meanwhile, Janice moves into her mother's house, where she soon gets a leg up on Livia's former housekeeper.

Dr. Melfi's attempts to steer Tony into behavior-modification therapy take a detour when a personal crisis gets in the way. Meanwhile, Ralph Cifaretto finds a way to endear himself to Jackie Jr.--but not to Tony.

Bobby 'Bacala' Baccilieri Sr. comes out of retirement to deal with a young hothead named Mustang Sally--much to the chagrin of his son and Uncle Junior.

Ralph's volatile relationship with a Bada Bing stripper and his obsession with the movie 'Gladiator' combine to put a damper on several boys'-nights-out sessions at the club. Meanwhile, at Columbia, Meadow's relationship with Noah is put to the test by her needy roommate Caitlin.

Tony convinces Uncle Junior to seek a second opinion for his cancer treatment. Meanwhile, Carmela debates whether or not to take Dr. Melfi's advice and see a shrink, Big Pussy's wife Angie regrets asking Carmela for some money to help her sick dog, and Christopher continues to endure a humiliating probation period at the hands of kinky Paulie.

As Thanksgiving approaches, Tony's feud with Ralph escalates, despite the intervention of Johnny Sack. At a frat-house mixer, Meadow and Jackie Jr. find they have more in common than mob-boss dads.

Tony gives Carmela a sapphire ring for her birthday...and Christopher gives Adriana her very own music club. Anthony Jr. gets busted for vandalizing the school swimming pool, but finds the punishment doesn't fit the crime. Tony test-drives a new Mercedes--and the Mercedes saleswoman, Gloria.

A somnolent visit with the ghosts of Christmas past lands Tony back on Melfi's couch. With the annual pork-store holiday party approaching, Bacala reluctantly agrees to don the Santa suit that Pussy used to wear. Tony and Furio have a holiday surprise in store for the Russian who roughed up Janice.

Paulie and Christopher are engulfed in a nightmarish journey into the South Jersey woods while trying to collect a debt from a Russian mobster. Meanwhile, Meadow is suspicious that Jackie Jr. is two-timing her, and Tony finds that family demands are jeopardizing his romance with Gloria.

Inspired by a tale from Ralph about how his father got 'made,' Jackie Jr. decides to 'make his move' in organized crime by instigating a robbery caper at a local card game. Reminded by Melfi of the psychological parallels between his relationships with Gloria and with his mother, Tony finds it harder and harder to spend time with his 'crazy love.'

Yet another academic misstep by A.J. forces his parents to contemplate military school. Tony orders Ralph to deal personally with the Jackie Jr. situation, and later seems to take Ralph's side in a money dispute with Paulie. Once again, the family gathers in Artie Bucco's restaurant, where Meadow reflects on being a Soprano.

Tony invests in a land deal despite Carmela's concerns about money. Junior faces his own financial woes as his trial approaches. Adriana brings her new friend to the Soprano Sunday dinner, but Adriana has no idea who Danielle is working for. Tony bonds with Christopher by giving him the opportunity to avenge the murder of his father.

With Paulie in jail, Christopher becomes acting capo, but he gets off to a bad start with Patsy. Still troubled by Jackie Jr.'s death, Meadow contemplates taking a year off from college to travel. Meanwhile, Adriana is in a bind after ending her friendship with Daniele, and Silvio discusses a misunderstanding at a Newark riverfront construction site.

Silvio and Ralph must take care of a planned protest of the Columbus Day parade by a Native American group. At an Italian pride ladies' lunch, Carmela is embarrassed by anti-Mafia remarks. Meanwhile, Ralph deals with new relationship troubles, and Bobby receives some tough news.

A disparaging remark about his wife sets Johnny Sack off on a vendetta. Meadow decides to do volunteer work at the South Bronx Law Center; Furio hosts a housewarming party for the gang; Silvio and Chris make an offer to an old-time hit man named Lou DiMaggio; and Tony and Carmela find themselves at odds over the family's bill-consolidation strategy.

Checking out Ralph's promising new filly at the track, Tony displays a flair for horse-racing strategy--and discovers an unexpected affinity for the stable life. Adriana finds her rock club being used as a place of business for Chris and his pals. Meanwhile, a court artist incurs the wrath of Uncle Junior, and Janice feeds Bobby in his hour of need.

After hiring an attractive French hostess, Elodi, Artie agrees to loan her brother some money, with interest. Meanwhile, Christopher gets some new responsibilities; Carmela fixes Furio up with an oral hygienist; Anthony Jr. becomes the 'dough boy' of a new rich girlfriend; and Tony receives some unsettling news about an old acquaintance.

Tony and the gang throw Paulie a Bada Bing bash after his release from jail, but it doesn't take long for old tensions to resurface. Carmela's cousin Brian throws out a hypothetical investment scenario that Tony and Ralph attempt to turn into reality with the help of Assemblyman Zellman and a black community leader.

Paulie takes pains to integrate his mother Nucci into the social world at Green Grove. Meanwhile, Furio faces up to his inner feelings during a trip to Italy to see his ailing father; Ralph introduces Tony to his new 'goomar,' Valentina; and Carmela finds a new source of investment income.

After an aggressive team of reporters lowers the boom on Uncle Junior, his lawyers try a new strategy. Ralph has some fun at the expense of Paulie and his mother, but soon winds up with his own family problems. Meanwhile, Tony again finds refuge at the stables.

At therapy, Tony likens himself to the 'sad clown,' but Melfi doesn't buy into his melancholy portrait. Meanwhile, Carmela drags A.J. with her to Furio's house to offer decorating tips and companionship; Paulie puts the finishing touches on some free artwork; and Christopher finds himself at a crossroads.

After a sitdown with Carmine and Johnny Sack, Tony contemplates the future of the HUD partnership. Meanwhile, Paulie blows off steam with an old pal; Janice starts losing patience with the obsessive Bobby; and Melfi ponders the Freudian undercurrents of Tony's latest dreams.

Tony continues to haggle with Johnny Sack and the two Carmines over the Esplanade profits. Carmela makes a decorating date she can't keep; Furio proves a reluctant companion to Tony on a casino junket; Paulie plays an impatient chaperone to some ladies from the nursing home; and Meadow debates the true meaning of a literary classic with her mom.

In the Season Four finale, Tony and Carmela contemplate purchasing a shore house, but a voice from the past threatens the deal. While Uncle Junior breaks out the Hearty Burgundy, Little Paulie and Benny break in a new sound system on the Stugots. With Carmine apparently intent on putting the past behind him, Tony and Johnny Sack weigh their options, carefully.

A flood of organized crime parolees changes the landscape of the Soprano/Lupertazzi alliance. Janice carries on the family's Sunday dinner tradition. Carmela and A.J. commune with local wildlife. Christopher balks at footing the bill on 'goomar night.' Tony tries to introduce Dr. Melfi to his 'other' self.

Tony sizes up a contractor's gift, then reunites with his paroled cousin, Tony Blundetto. Paulie and Christopher relive some not-so-special memories. Carmela launches a film club. Adriana grapples with her guilt. A familiar figure 'crosses over.'

Tony's power-sharing plan doesn't fly with Johnny Sack, who makes his point through a bookie named Lorraine Calluzzo. Out on parole, Feech La Manna crosses Paulie in his attempt to break into the landscaping business. Tony gets a roommate. Junior looks into the past while testing the patience of those closest to him.

Carmela and Tony reunite, if only to discuss Anthony Jr.'s dwindling college prospects. Feech takes Tony's crew on a trip down memory lane. Lorraine's allegiances get her into hot water. A.J. has a night to remember in the Big Apple.

While Christopher is away, Tony gives Adriana a ride home that proves disastrous. Meanwhile, the Soprano crew plays a game of 'telephone' with the story that turns it into something far more sinister when an enraged Christopher gets wind of it.

With her son's future at stake, Carmela puts in some extra time with his college advisor, Robert Wegler. Meanwhile, Tony Blundetto realizes it's hard doing business with strangers, and A.J. concludes there's no place like home.

His father's longtime goomar sheds light on some of Tony's lingering emotional and financial mysteries. Meanwhile, Junior sees the upside of attending the funerals of fringe relations, while Christopher sees the downside of enabling an A.A. friend's new addiction.

Friends and family gather at the Sopranos' for a not-so-surprise 75th birthday party for Carmela's father, Hugh. Meanwhile, Johnny Sack shows off his new wheels, Phil Leotardo pulls into Pussy's old place for some auto repairs, and Tony B. considers accepting a familiar job on the side.

A rumor involving his cousin puts Tony's relationship with Johnny Sack back on thin ice. Meadow helps get her boyfriend Finn a job. A.J. ponders a 'maximum-security summer' at Casa Carmela. Melfi links Tony's current guilt to a past job. Carmela learns that good legal help is hard to find.

Tony B. and Christopher unearth some old memories during an otherwise idyllic trip to the country. Tony and Carmela plan another party. Janice lands in anger-management therapy after a sports-rage incident. Benny and Terry solve a missing-Vespa mystery. Tony puts his sister's newfound serenity to the test.

Tony escapes to the Plaza Hotel for a night of rest and relaxation, but his dreams are haunted by past faces. Another casualty falls in the war between Johnny Sack and Little Carmine, and Tony B. heads to New York for revenge.

With the feds pulling a new trump card, Adriana ponders her options. Tony B. unloads some heavy baggage on Tony, and vice-versa. Johnny Sack makes Tony an offer he can refuse, and Tony offers Carmela a deal to make her real-estate dreams come true.

In the Season Five finale, Tony's crew circles the wagons as Johnny Sack turns up the heat. Carmela counts her blessings. Christopher is freaked out by an unexpected visitor. Benny's connection to the plumber's union comes in handy. A.J. demonstrates his business acumen. Tony ponders whether to execute a 'sacrifice bunt.'

Gene Pontecorvo makes a final break from the mob life, while Junior's paranoid delusions could be the end of Tony.

The family tries to cope with Tony's hospitalization and possibly impending death, while Tony begins to hallucinate a new life parallel to his own.

While the gang begins to turn on itself, Tony finds himself at the threshold.

Tony goes home and returns to business, perhaps with a new frame of mind. Paulie receives a shock about his mother.

Johnny Sack asks for permission to get out of jail for his daughters wedding; Tony's on the look out for personal protection.

Tony seeks guidance from overseas to solve a local problem; and decides whether a top earner deserves another chance.

Chris meets and beats the stars, while Artie turns violent after having his hospitality abused.

Vito considers starting a new life in New Hampshire, while Anthony continues his pursuit of revenge against Junior.

Paulie finds public opinion turned against him after an amusement ride accident, while Chris tries to start a new life as a husband and father.

Tony reflects on how growing up with Janice colors his attitudes now, while Vito tries to make a new life for himself in New Hampshire.

Phil takes out his revenge on Vito, while Tony grows frustrated with Anthony's lack of ambition or work ethic.

Phil Leotardo seeks to continue a cycle of retaliation between the New York and Jersey families. Christopher wrestles with his addictions. Tony decides keeping Carmela occupied with the spec house is for the best. A.J. gets a new girlfriend.

Bobby and Janice host a wild 47th birthday bash for Tony at their Adirondacks vacation home. Tony's actions following Johnny Sack's arrest come back to haunt him.

Christopher's Cleaver premieres, showing Tony how he feels about him. Johnny Sack faces a health crisis. Phil Leotardo resents his family, and himself, for being weak and downtrodden. Silvio gets caught up in New York's power vacuum.

When Tony's first hit is about to be unearthed, he and Paulie flee to Florida, where Tony contemplates their friendship. Junior organizes a poker game at the institution. The New York power struggle continues.

Maria Spatafore requests help from Tony for Vito, Jr. Tony's bad luck puts a rift between he and Hesh. A.J. makes a major choice regarding his future.

The relationship between Christopher and Paulie's falters, while A.J. grows depressed over his break-up with Blanca.

The Soprano and Lupertazzi crime families quarrel over asbestos removal. Tony deals with a problematic associate. Paulie suffers a devastating personal loss. A.J. questions his friendship with Jasons Parisi and Gervasi.

Tony attempts to repair the rift between New Jersey and New York. A.J.'s depression struggle continues. A New York associate crosses the line with Meadow.

The spectre of disloyalty among the crew hangs over Tony as Phil Leotardo decides how to handle recent issues with the Soprano crime family. A hit gone wrong comes at a huge cost. A.J.'s conquering of his depression is challenged.

Tony seeks to find a peace with the Leotardo crew while dealing with rumors a member of his own crew may have flipped. A.J. makes a decision regarding his future and Junior's slide into dementia continues.