Despite ever-increasing tension between Walt and Skyler, he pulls out all the stops in an effort to reconcile with the family. Elsewhere, Saul is instrumental in getting Jesse involved in a most-unusual investment opportunity.

Walt loses control as he reacts to Skyler's news, endangering his job and relationships with Saul and Jesse. Hank throws himself into his blue meth investigation. Jesse enacts a new plan.

The family waits for news about Hank. While Jesse covers at the lab, Walt attempts to placate Gus. After witnessing a disturbing outburst, Walt worries he and his family are in danger.

As Hank's hospital bills stack up, Skyler hatches a plan. Walt and Gus come to a better understanding. Jesse, looking for more independence, pursues a new opportunity.

Against Walt's advice, Jesse lashes out. Fearing for Jesse's safety, Walt takes drastic action to intervene and tragic event leads to a shocking confrontation.

With Jesse on the run and Mike in hot pursuit, Walt negotiates a bargain with Gus and concocts a disturbing plan to provide for his and Jesse's safety.

Walt and Jesse face the deadly consequences of their actions. Skyler deals with a puzzling disappearance, as Marie struggles to help Hank with his recovery.