Barker Bill's Cartoon Show was the first network television weekday cartoon series, airing on CBS from 1953 to 1955. The 15 minute show was broadcast twice a week, Wednesdays and Fridays, at 5 P.M. Eastern, although some local stations showed both episodes together as a single 30 minute show.

Barker Bill was a portly circus ringmaster with a long black handlebar mustache and dressed in the traditional costume - a fancy suit with white gloves and a top hat.

The show was hosted by a stationary picture of the Barker Bill character with an off-camera announcer introducing the cartoons. The show featured old black and white cartoons obtained from Terrytoons. These were mostly older cartoons from the 1930s, like Farmer Al Falfa and Kiko the Kangaroo, not the more current and better known series such as Mighty Mouse and Heckle and Jeckle.

Barker Bill did not appear in cartoons, but was briefly featured in a newspaper comic strip series.

Terrytoons was the first major animation studio to give television a license to show its library of old black and white cartoons. The Barker Bill series was so successful, that that CBS offered to buy the Terrytoons studio, including its production facilities and library of cartoons. Paul Terry accepted the offer and retired in 1955.