Needing the help of the street fighters, Dhalsim summoned them to his remote mountain temple by causing Blanka considerable mental pain. It seems the Satin Hammer was back, and wanted to steal an atomic bomb that Dhalsim currently had in his possession. Guile brought Blanka, T. Hawk and Sawada along with him, even though feelings still existed between T. Hawk and the Satin Hammer. Eventually the street fighters stopped hammer's plot when Dhalsim deactivated the atomic bomb's countdown timer.

A crime wave has taken over London, and Bison is thought to be the one responsible, so Guile, Cammy and Honda team up with the team at MI5 to take Bison as well as Birdie and Sodom down. During the fight, Bison seemingly takes over Cammy's mind, and she immediately switches allegiances. With a backup plan in full readiness, Bison and Cammy manage to escape. This is much to the chagrin of Guile, who screams at them as they fly away.

Chun-Li is attacked by mysterious mutant assailants, as well as having her TV crew kidnapped. She calls for Guile and Blanka's help to track them down, which leads to a search of the sewers. They soon find out that a former scientist of Bison's is continuing mutant research and mutated 3 thugs into half-man/half eel/alligator/bat warriors. In the ensuing battle, Blanka receives a mega-dose of mutagen ooze, which turns him even more feral.

While visiting their master Gouken, Ryu and Ken are challenged by the evil Akuma who claims to have stolen Gouken's chi and will do the same to them. Akuma gives Ryu and Ken time to train so they might stand a chance against him. During the course of their sparring sessions however, Ken injures Ryu's arm, which leaves Ryu in a bad state. Akuma uses that to easily defeat Ryu, only to get defeated himself by the power of Ken.

Ryu and Ken are asked to help Fei Long with his latest movie project. Investors in the film however pull funding out of the movie, which leaves Fei Long with no way to raise awareness about the evil crime boss, Lo Fat. Ken is forced to ask his father to re-invest in the film, so it can continue. Ken gets creative license for the script, and writes himself in as the star instead of Fei Long. Both men have a climatic showdown, which results in Ken burning down the entire movie studio.

Guile and Blanka take a trip to the Middle East to cool hostilities between Arabs and Israelis, but Blanka's temper gets the best of him, and he attacks them all. Vega, watching this drama unfold on a prison TV set, swears revenge against Blanka for destroying his face. Vega easily escapes, and flies to Hawaii for a final battle while taking Mei Lei, Blanka's love interest, hostage. Blanka almost manages to kill Vega, but with the combined efforts of Mei Lei, Guile and Chun-Li, they were able to prevent Vega's tragic death at the hands of Blanka.

Bison charges Cammy and his cybernetic creation La Lupa, to steal a priceless Kali statue for him. The statue has meditative powers that Bison hopes will help him heal his wounds from his previous battle with Guile. The street fighters team up with MI5 to help get to the bottom of Cammy's switched allegiances and during the battle, Cammy gets knocked on the head which frees her from Bison's mental control. Cammy then lures the street fighters to Bison's hideout, where she betrays them once more. Bison and Cammy are then able to escape.

The mystical psychic Rose, senses that powers in the world are fluctuating wildly out of control. She blames Ken and Blanka for this sudden energy spike, and believes they are the catalysts to the end of the world. Rose kidnaps them both and forces them to fight only to realize they are not evil at all. With their help, she tracks down Bison, who is the true manifestation of evil she had sensed. She then attacks Bison in the mental world just as Ken and Blanka destroy the kali statue, which destroys Bison's entire castle. Mysteriously, everyone in uninjured, and Bison eludes capture once more.

Blanka searches the jungle for a mysterious healing plant that could revert him to his normal form. Guile and Lucinda go to track him down, and hear the same story of the plant from the jungle natives. Blanka then encounters a wild jungle boy who swears revenge against the natives for killing his family. The boy is actually an alien who had crash-landed on earth along with his family. Blanka befriends the boy, and along with Guile and Lucinda, they defeat the evil natives and the boy returns to his home planet.

Ryu is a legend in Shadowlaw, and Sakura is his most adamant admirer. But when Sagat patrols the streets regularly making sure to burn down any building with posters of Ryu in it, Sakura leaps into action. She boards a plane headed for New York to seek out her idol, who had just been visiting Ken in the hospital, as Ken swallow some water while on a mission in Africa. Ryu meets Sakura, and she convinces him to come to Shadowlaw to defeat Sagat once more. Sagat welcomes the challenge, and he and Ryu have another epic confrontation.

The plot of this episode is based on the arcade game with the same title. The new mayor of Metro City Mike Haggar, has his daughter kidnapped by the Mad Gear gang, so it's up to Ken and Ryu to save her. Escher, Guile and Haggar devise a plan to put Ken and Ryu undercover to infiltrate the gang, which Cody takes exception to as he constantly screams at everyone in protest. Eventually Ken and Ryu meet with Belger, the boss of the Mad Gears, and along with Cody and Guy, are able to save Jessica. Haggar breaks down a door at the very end, and Guy kicks a rocket back at Belger.

Bison captures the MI5 team in a brief battle, and the British government are adamant about getting them back, as they know critical government secrets. Bison compiles doomsday codes, which are the launch protocols for every known nuclear bomb on earth, and plans to not take over the world, but to destroy it. Guile and Chun-Li are given a package from Sagat, containing the secret of Cammy's past, as Sagat does not want the world destroyed by Bison. They infiltrate Bison's base, and everyone, including MI5, team up to stop Bison, and destroy his computer console with one second left on the doomsday timer.