Eli Stone finds his life at a crossroads and soon learns that he suffering from an inoperable brain aneurysm that's causing his hallucinations. Struggling to cope with the news, Eli begins to have visions that he is a prophet and decides to use his new found abilites for good.

Eli's new position at the law firm means that he does not have an office, secretary or the power to take cases. Eli takes the case of a 15 year old boy whose mother was killed due to a medical malpractice by Dr. Agon. Dr. Agon worked at the hospital where Nathan works, Eli will have to sue the hospital. Jordan, in the meanwhile, assigns Maggie to be be Eli's head and so Eli has no choice but to take instructions from her. Taylor, however, organizes a live performance by George Michael to square things up with Eli.

A teenage girl is expelled from school after playing George Michael's "I Want Your Sex" during the assembly. Jordan alongside Eli takes charge of the case, but Eli fails miserably in hiding his obsession for George Michael. Eli is motivated to go on date with Beth Keller, the girl with whom he had sex for the first time and who happens to know a big secret about Nathan. In the meantime, Taylor and Matt are working together on a case in which they are representing a judge suffering from cancer. They decide to sue the judge's son when he refuses to donate the bone marrow for his father.

Eli goes in for an operation on his aneurysm, but it doesn't go as planned and Nathan is left with a difficult decision.