Isagi Yoichi, a first-year forward, loses his chance for the Nationals because he has passed the ball to his fellow player in front of the goal. That's when he receives an invitation for Blue Lock. It's a facility to train one world's greatest striker out of 300 high-school-aged forwards so that Japan can win the World Cup.

The first selection is the round-robin tournament of five teams of V, W, X, Y and Z in Building Five, with only top two teams being eligible to move forward. Isagi's Team Z, the lowest ranking team, plays against Team X. But because of the special rule that allows the top scorer of the team to proceed to the next section, the match turns into chaotic scrambling for the ball, regardless of the teams. It was Barou Shoei, Team X's formidable striker, who changes the flow of the game.

Each player unleashed their weapon and ego, and Team Z has caught up to a draw. They totally have the momentum of the game, but that has “awakened” Team V’s monster, Nagi. In the chain reaction to awakening, Isagi also learns to use his weapon and keeps fighting. The “heat” generated by the clashing of ego from both teams starts to affect Kuon as well.

The thrill of finally finding the "monsters" with overwhelming talent became short-lived, as Bachira realizes he's being left behind in the battle between Isagi and Rin. Meanwhile, the game is reaching its final stage, with a fierce back-and-forth battle led by the wild card, Barou. As Isagi takes his skills to the next level under extreme conditions, Bachira is forced to confront his own "ego" amidst the intensity of the situation. Where will their newfound powers take them, and what impact will it have on the game's outcome?