Over the last century at least four thousand four hundred people who were overlooked, undervalued, or otherwise marginalized vanished without a trace off the face of the planet. Last night, inexplicably, they were all returned in an instant to Detroit having not aged a day and with no memory of what happened to them.

As the 4400 become even more disenchanted with their accommodations, new rules have everyone on edge. Andre and LaDonna help Claudette push her newfound ability to new limits. Shanice gets an unexpected visitor.