In 1850, Captain Charles Boone inherits his wealthy cousin's estate and relocates his family to small-town Maine where the Boones encounter prejudice, hostility, a mystery illness and murder as Charles begins a dangerous journey of self-discovery.

A child in town dies of a mystery illness and on her deathbed, credits Stephen Boone. Hysterical townsfolk demand that Charles dig up his cousin's grave. Charles refuses, but in private opens the grave and is shocked by what he finds.

Charles continues to hear rats behind the walls, despite assurances there are none. His search for answers leads to an insane asylum where his worst fears are realized.

The mysterious Jakub lures Charles to Jerusalem's Lot and he discovers that his madness is connected to an ancient book. The children are stunned and betrayed when Loa finds Rebecca's secret writings about the Boone family.

Charles is overwhelmed with grief and anger after his family is dealt a devastating blow. Stephen and Uncle Phillip come to Charles with a surprising proposition.

Overwhelmed with madness, Charles is driven to the church cemetery where he unearths a hidden book. Once in his hands, he has an apocalyptic vision of the vampire future.

Charles and his family defend Chapelwaite with the help of Constable Dennison and Minister Burroughs. The night tests each character to their emotional limit.

Charles and company try to enlist men in town to fight in Jerusalem's Lot and retake the book.

Jakub and his army come out of the dark and attack Charles and his fighters. Charles must make a decision to free his family of the ancient book's curse.