The Cube is back! Dwyane Wade returns with the world's toughest game show. We are launching the second season with some VERY special guests as Gabrielle Union-Wade and La La Anthony take on brand new games in The Cube for charity.

As Kweku & Kofi give the Cube the best they've got, we welcome nurses Natasha & Kiana, who are confident they will conquer the Cube with their sporting background and surgical hands.

Wanda Dench shot to viral fame when she accidentally texted stranger Jamal Hinton when she intended to invite her grandson over for Thanksgiving. Six years on, these unlikely BFFs take on The Cube, hoping to be thankful for a 250k windfall.

The Cube is faced with a competitor like no other as NBA legend Shaquille O'Neal takes on the Cube in a solo attempt to win money for charity. It's man vs. Cube as the champion pushes the Cube to its limits!

The Cube might have met his match when Baltimore BFFs Brianna and Niyah show the Cube a thing or two about attitude. Will their partnership and determination be enough to walk away with the bag?

Best friends and fellow teachers John and Dave set out to teach the Cube a lesson, but learn that it's their relationship that's put to the test as they fight it out to try and win $250,000.

Can Dr. Libby and daughter Kelsey use their family bond to outwit The Cube as they continue on their quest to win big? Their 'all or none' approach has left Dwyane Wade with his jaw dropped! Will they be the first to beat the Cube?

Cheer coaches Tommy & Jermaine tumble into The Cube. But can they turn their positivity into cold hard cash? We then meet brothers Brian and Branden from San Francisco, California. Could they be the first to crack the Cube?

Two brothers from San Francisco continue their game in The Cube with their eyes on the 250k prize. With their complementary skills, puzzle solving approach and unique team dynamic, will our 25th team be the first to beat the Cube?

The Cube welcomes youth ministers and married couple Larissa and Luis as they take on the Cube backed by a higher power. On a mission to raise funds for their work, will the Cube give them its blessing?

Texas Cowboy's Ben Senior and Ben Junior are out to tame The Cube and bag themselves a quarter of a million dollars. Can the father/son duo use their family bond and Cowboy tactics to beat The Cube or will it be pistols at dawn?