Młody Dyrygent, Takt, wraz z swoją Muzą i jej starszą siostrą zmierzają do Nowego Jorku, w celu dostrojenia owej Muzy. Z uwagi na zainteresowanie każdym możliwym instrumentem, Takt, dość często przyciąga do siebie uwagę D2. Ich podróż to ciągła walka z wielkimi wrogami muzyki.

Wracamy do wydarzeń sprzed pierwszego odcinka, do momentu, kiedy Takt i Crosette byli dwójką zwyczajnych ludzi. Jednakże los, który zbiera swoje żniwo, nie patrząc na okoliczności i wiek osób, przygotował dla nich nową drogę. Drogę, której celem jest chronienie muzyki.

Cosette transformed into the Musicart named Destiny. Destiny proclaims that her mission is to eliminate the D2s. Destiny bestows a conductor's baton upon Takt, and he uses his Conductor powers for the first time. And then, they are confronted by two individuals: Lenny and Titan. They are an official Conductor and Musicart from the New York Symphonica, which was the strategic headquarters to fight the D2s.

Takt and Destiny learn how to fight properly from Lenny and Titan as they continue to make their way to New York. However, Takt and Destiny still have a hard time being in sync. They then coincidentally run into Lenny's old buddy Jonathan. Jonathan then leads them around his home, Las Vegas.

Takt and crew stop by a certain town. All of the young people had fled the town, leaving only the elderly. The residents happen to ask Anna and Destiny for help. Meanwhile, Takt wandered around town on his own and happens to hear a melody quietly resonating from an old bar. It was definitely the sound of music.

Anna and Destiny happen to see a town destroyed during their travels. D2s are awakening everywhere and attacking various towns and people, reverting the world back to four years ago, before Sagan's Declaration. As the threat from the D2s grew, Takt was obsessing over something. With a blank staff notation in front of him, Takt plays an imaginary keyboard as he desperately tries to create something.

D2s awakening. Takt's hometown being attacked, and Cosette's death. This was all a part of Sagan's plan. Shindler wants to get rid of all those inferior to him in this desolate world. After learning the truth about Cosette's death, Takt charges at Shindler in a blind rage. But Takt is injured by Hell. As she witnesses Takt injured and bleeding, Destiny feels some emotions welling up inside of her that she's never felt before...

Takt and crew finally reach their destination of New York. They reunite with Charlotte, Anna's older sister, who works for the Symphonica's technological development department. Charlotte begins to examine Destiny. Who is an incomplete Musicart. But then, Anna realizes something is wrong with Takt. The mark on Takt's right arm starts to spread to the rest of his body, and...

Lenny remembers his own past. Lenny recalls someone very dear to him. Everything leading up to today was so that he could do everything he could to do what he had to do. Lenny heads to the meeting point along with Titan so they can tell Takt and Destiny everything. But someone rather unexpected was waiting for them.

A giant Black Night Siderite starts to stir as Sagan hums a certain melody. The Black Night Siderite that grows as big as a tree starts to swallow up the New York Symphonica. Sagan has finally made his move to make his ambitions come true. As Takt and Destiny witness this eerie spectacle, they find out that Anna and Charlotte are still inside the Symphonica.

Destiny is terribly cruel. But no matter how much misfortune the gods torment me with, I will face my destiny. Because of that, I fought, and I fought, and I fought some more... And then, I finally found my answer. There truly was joy beyond the pain. Now, it is time for the performance to begin. I shall now wring destiny's neck. "From a certain man's memoirs"