Best friends Hart and Robby look forward to graduation until Hart discovers his doctoral status is in jeopardy when he is reassigned to an elite team of ecological technicians (EcoTechs) due to a genetic flaw.

Hart and Jakki are assigned to the Initial Response (I.R) Squad front lines replacing two Eco-Techs killed in the line of duty. Jakki's life is threatened when her air tank fails while working on a hazardous assignment. Rome grows suspicious of her new roommate Pen when she discovers a listening device under her bed.

Hart and his EcoTech comrade Rat accuse each other of sabotage when Hart discovers his helmet air-hose has been mysteriously severed. The cunning Dr. Rich finally agrees to meet with Robby to discuss Hart's medical condition, only to blackmail him into spying on Hart, his best friend, for Nexes. While Medical Security interrogates Hart, Rome meets a new confidant.

After being wrongfully accused of insurrection, Hart risks having his memory destroyed through a new technique designed by Nexes. Hart, Robby and Rome take a risk to retrieve Hart's genetic records with the help of a hacker.

Rome and Hart rush to the P.A.S (Progressive Aging Syndrome) hospice upon receiving news that Uncle Jake has taken a turn for the worse. They join forces with Jakki devise a scheme to grant him his final wish. After Hart and Rome say goodbye to Uncle Jake, he leaves them with some curious words of advice and an interesting gift. Meanwhile, Robby reluctantly continues to work as an agent for Nexes and Rome's new friend Abby turns out to be no friend at all.

After Medical Security interrogates Hart and Rome about their Uncle's disappearance and his missing medication, Jakki and Hart break into a Nexes lab to test the strange medicine. Meanwhile, Dr. Rich closes in on her prey with help from her newest and most valuable ally, Robby.

When Hart and Jakki go underground to visit a member of the dissident group, The Storm to analyze Uncle Jake's medication, they are shocked by the test results. Meanwhile, Rome uncovers the truth about Pen's tragic past.

Desperate for a second opinion on his Uncle's medication analysis, Hart turns to Robby and his connections at the Nexez medical labs. While Dr. Rich closes in on Jakki, Hart and Rome and their links to The Storm, Hart and Robby question each other's loyalties and threaten their friendship.

Hart is suspicious of Nexes' motives when Rome is offered a lucrative research internship at Nexes' P.A.S. laboratory. His suspicions are confirmed when she is caught investigating a mysterious medical experiment and is jailed by Nexes.

Nexes sentences Rome to be genetically remodified, a process where a dissident's genetic makeup is destroyed and reassigned. Hart must face three rigorous tests to gain entry into The Storm and find help for Rome before it is too late.

Hart lets Nexes capture him in order for him to gain access inside Nexes to help Rome escape but the plan backfires. Rome faces her worst fear-genetic remodification.

Jakki's effort to save Hart result in Nexes removing her protective implants but Hart and Quixote manage to save her. The identity of Hart's mischievous helper Quixote is finally revealed -or is it?