Dwayne and Whitley run into each other on a flight back to school. Whitley finds that Dwayne has changed over the summer, as he is dressed in an expensive suit and seems to have matured during his successful internship at Kinishewa. Dwayne comforts Whitley when the plane experiences turbulence. Whitley kisses Dwayne in front of her entire dorm, prompting much teasing from her friends. Each insists that they are only friends. Whitley goes to Dwayne's apartment to see him, but is turned off when she finds him dancing like an idiot at a party. The residents of Gilbert Hall struggle to adjust to the fact that the dorm is now coed. Walter is the resident director, with Jaleesa as resident assistant.

Whitley has yet to take a basic math course that is required for graduation. She reluctantly enrolls in Col. Taylor's class, and he tries to help her overcome her fear of the subject. Dwayne and Ron clash over finances. Dwayne believes that Ron spends money too freely, while Ron accuses him of being a cheapskate.

Dwayne struggles with an assignment for poetry class, as the students must compose their own verses. William Shakespeare appears to him in a dream and stresses that his pursuit of a career in math does not mean that he cannot also appreciate poetry. He encourages Dwayne to write about something for which he feels passion. Whitley reads Dwayne's beautiful poem and believes that it is about her. She is angry and embarrassed when the rest of the class interprets the poem differently; it is actually about Dwayne's love of mathematics. Freddie juggles dates with environmentalist Livingston and Ron's handsome friend Ernest. Although neither relationship is exclusive, she feels guilty until she sees Livingston with another girl.

Dwayne, Ron, Kim, Freddie and Ernest head to Devil's Island, South Carolina for spring break. Whitley joins them at the last minute after Julian has to cancel their vacation due to a job interview. Ernest has big plans for Freddie, but passes out drunk. Ron tries to put the moves on Kim. A pair of murderous drug dealers searches the gang's van for a missing duffel bag. Dwayne and Ron discover money and drugs in the bag and try to go the police. Freddie and Kim meet the drug dealers on the beach and flirt with them, unaware that they are criminals. Dwayne and Ron return to the house after missing the ferry. Dwayne overhears the men threatening to kill him and tries to make a break for it.

Julian shows up to surprise Whitley, who wants nothing to do with him. Dwayne and Ron dress like women to get past the drug dealers and onto the ferry. They arrive at the police station to discover that they accidentally brought Julian's bag instead of the one with the drugs and cash. Paul and Eric search the house, failing to recognize Dwayne and Ron (who are still disguised as ""Diana"" and ""Rhonda""). They promise to return that night. The gang fears that the police will not make it in time because a storm has cancelled all ferry service. Kim, Freddie, Ron and Mandy head out in search of help. Whitley decides to sleep with Julian, but he doesn't think the timing is right. Dwayne hears the dealers coming and bursts into Whitley and Julian's room. Whitley gets into an argument with Dwayne after telling him that she is a virgin. As she opens the door to get him to leave, she gestures with a candlestick holder and cracks Eric over the head. The trio struggles with the men until Walter and