A misdiagnosis by Arch leads to a tuberculosis scare in the department. Gosia lies while testifying at Wayne's hearing resulting in the assault charge against him being thrown out of court. The temporarily closure of the bathrooms in the ER causes some tense moments for Marina. Oopy's practical joke leaves him with a bad taste in his mouth.

Marina hands in her resignation after being in a car accident that kills a patient to whom she was giving a ride home. Bree abruptly ends her relationship with Arch after introducing him to her family. Red's quiet day with his wife and newborn son (Alexander) ends in tragedy when a young boy falls off a ferry. A stranded climber requires rescuing

Bree and Gosia discover that Oopy is moonlighting at a private cosmetic surgery institute, Olympia's Secret, when a medivac returns with one of the institute's former patients who is now suffering from complications arising from her surgery. With the help of Peter, and his newly acquired pilot's license, Bree and Gosia take to the air to notify the institute's patients of the possible dangers associated with unnecessary cosmetic surgery. One of Arch's first official actions as the hospital's new Deputy Director results in a funding dispute between two charities

Medical practices in the ER are publicly condemned by hospital neurosurgeon Dr. David Delamere resulting in Arch being investigated on a charge of manslaughter relating to the death of one of his patients. No longer able to emotionally let go from her patients, Macy quits and takes a job in a nursing home. Monsignor Duval, a representative from the Vatican, arrives to investigate a potential miracle for which Wayne is the principle witness

The emergency department is quarantined when Nikki is believed to have a fatal rabbit virus. Dave Callen, Marina's medivac pilot, is blinded following an inflight explosion but Marina is able to successfully talk him through an emergency landing. Wayne attempts to sneak out of the hospital so that he can attend a stamp auction

Sean's best friend is diagnosed with a progressive nerve disorder and lapses into a coma. Julia passes over Gosia for the new Nurse Manager and instead appoints the unpopular Eric Frost to the position. A professor of Jewish studies overdoses on his housekeeper's pills trying to induce vomiting after eating pork. His asthmatic housekeeper is then brought in after having run out of her medication. Evie and Sean end their relationship.

Sean, Evie, and Gosia are called out on a medivac to treat a nine-year-old boy with a broken leg but instead find a group of homeless kids living in an underground sewer complex and a middle-aged man with an unknown illness. Returning to the hospital, Sean and Evie eventually diagnose the man as having an obscure 16th century sweating sickness and convince Arch to let them treat him with an equally obscure 16th century remedy. After their brief first encounter in a bar, Marina becomes a strange man's object of affection as he sends her flowers and begins to hang around the hospital. Tom refuses any cancer treatments that may prevent him from returning to work, but an unsympathetic Arch just wants him to be replaced.