In the season premiere, Katherine was a bright college student with dreams of becoming a journalist until she was abducted and brutally assaulted. Katherine swiftly spiraled, becoming dependent on a dangerous mix of drugs to mask the trauma. Her parents have already purchased a burial plot for her and are certain that it’s only a matter of time before they bury their only child.

A woman battles a heroin addiction that surfaced after her fiancé was murdered in front of her.

A successful businessman who underwent back surgery develops a life-threatening addiction to pain pills and hand sanitizer.

At the age of 22, Shiann has already faced a lifetime of pain. The shocking death of her sister, a diagnosis of A.S., a progressive and debilitating disease, and an unexpected divorce, sent this once vivacious fitness model and bodybuilder down a path of meth-fueled binges. With no help in sight, her family fears losing another loved one to an early death.

A woman who slipped back into a life of crack cocaine and heroin abuse sells her body to support her habits; family members fear she will lose more than just the custody of her son.

A student's decision to stay in a local high school with his friends instead of attending a school for gifted teens leads to a life of partying and an addiction to heroin and fentanyl.

A woman gives up using crystal meth and heroin following the birth of her two daughters, but soon falls back into addiction and loses custody of her children.

The haunting memory of childhood molestation causes a tae kwon do prodigy to turn to the numbing effects of drugs at the age of 15; six years later, the former athlete is deeply addicted to crack cocaine and IV opioids.