A young sailor named Billy Bosko married his high school sweetheart, Michelle Moore Bosko. When he returns to his home port of Norfolk, Virginia on July 8, 1997, he finds his 19-year-old bride lying on the floor in a pool of blood. She had been raped and murdered. The police investigation focuses on a neighbor, who confesses. But his DNA does not match the killer's. That begins a series of police interrogations and "confessions," all of which are in conflict with the forensic evidence. Four men are eventually sent to prison. Three others are accused. Finally, an eighth man confesses in a letter, and his is the only DNA that matches. Defense investigators and others wonder why were the other men accused and sent to prison.

Beginning in December 1990, police uncover a string of murdered prostitutes. Each victim has had her eyes carved out. Charles Albright was eventually convicted of murder in 1991.

Several monks are massacred at a Buddhist temple in Arizona in 1991. Four men from Tucson, referred to as the "Tucson Four", were initially charged with the crime and gave confessions under controversial conditions, including the actual murder weapon – connected to unassociated individuals who were ignored by authorities – being left untested by the sheriff's department. However, the "Tucson Four" later recanted the confessions and were released when investigators finally confirmed that they had nothing to do with the murders. Local teenagers Johnathan Doody and Allessandro Garcia were arrested and imprisoned.

Over 40 years after the 1963 assassination of president John F. Kennedy, a majority of Americans still believe that there was a cover-up. Was Lee Harvey Oswald the sole gunman? Could one bullet pass through both the president and governor John Connally? Does a police radio recording hold the truth?

The 1932 kidnapping of Charles Lindbergh, Jr. is reviewed.

A look back on 25 years of Forensic Files/Medical Detectives, featuring interviews with key figures behind the scenes as well as highlights of favored episodes and scenes.