Richard Sackler begins to launch a powerful new painkiller, a rural doctor is introduced to the drug, a coal miner plans her future, a DEA Agent learns of blackmarket pills, and federal prosecutors decide to open a case into OxyContin.

OxyContin is on the market but faces a potential threat, Purdue’s vast influence reaches the town of Finch Creek, Bridget steps outside her DEA authority, and the criminal investigation of OxyContin begins.