Dr. Phyllis Thackeray diagnoses the cook at the Barton Ranch with smallpox. All the cowhands may be infected and need to be vaccinated. Dr. Thackeray sends for the one man she thinks can help.

After she attempts to shoot Rudy Rossback and fails, Eve McIntosh offers Paladin $1,000 to kill him. After Paladin turns her down she hires another gunman.

A poker game takes a deadly turn and Paladin is caught in the middle.