Motoko is asked by her friend Kurutan to investigate a strange scenario. A six-year old girl's life was saved by an immediate heart transplant. When her parents tried to send their gratitude to the donor, the donor's parents filed a police report since they never gave permission for the donation.

What's more, the investigating officer has now been hospitalized after an accident. There is more to this case then meets the eye and Motoko and her colleagues must find out who's behind these apparent illegal organ donations.

While tracking the New World Brigade, an anti-cyberization group, to an unused radiation scrubber facility off Okinawa, the Japanese Maritime Safety Agency took pictures that show Eka Tokura, the kidnapped daughter of a cyber-technology company CEO. However, the girl had been abducted over 16 years ago when she had been 10 years old. In the recent photos, she looks just as she did on the day she was taken.

For reasons unknown, contact with the Maritime Safety Agency's reconnaissance team has been lost. Section 9 heads to the facility to locate the unit and find out why Eka Tokura was there.

A new sniper device is tested out, but is found to have flaws. While Section 9 attends a debriefing session on the fate of the sniping device, the Tachikomas themselves begin to worry that tomorrow they could be the ones that are scrapped. The Tachikomas of Section 9 unite and discuss the various issues dealing with them that have occurred within previous episodes. They worry that the Major does not appreciate them. At the same time, the Major is looking into the idea of proceeding without the Tachikomas at Section 9's side.

"Machine désirante (Desiring-Machine)" is one of the key concepts of Anti-Œdipus, written by contemporary French philosopher Gilles Deleuze.

After the events of "MACHINES DÉSIRANTES", the Tachikomas are sent back to the lab for further testing. Batou has little time to ponder the loss of his pet, however.

A foreign spy is suspected to be working within a Japanese Self-Defense Force training camp based in New Port City. With the Major and the Chief away at a security conference in England, Batou alone is assigned to go undercover to confirm the suspect.

Aramaki and Kusanagi attend an international security conference in London. While there, Aramaki visits an old acquaintance of his, who is the operator of a wine fund, a place where people store their wines in order to let the wine age and become more expensive.

Their meeting is not purely a social one, but before Aramaki and his friend can sit down and talk about the old days, the bank is broken into by two mafia men.

Following the events of the "RE-VIEW", Togusa has been rushed to the hospital. Just before he goes into surgery, he passes what he has learned to the rest of his team.

As he fights for his life, his colleagues at Section 9 take over the case to find the vaccine recipient ledger and the person responsible for taking it. However, others in the government are not happy about this investigation. The Drug and Narcotic Suppression Squad, the same unit that had shot Togusa in the previous episode, is again dispatched by the Ministry of Health, Labour, and Welfare in order to find the thief and the ledger before Section 9 does.

Togusa, at the request of Chief Aramaki, returns to work. Both head out to the Prime Minister's residence with a detailed report citing Secretary-General Yakushima as the real power behind the Laughing Man Incident.

However, before they can even leave their own building, they are told by the Minister of Home Affairs that Public Security has already been accused of being the masterminds behind the Laughing Man. The situation has gone from bad to worse and it will take a concerted effort by all of its members for Section 9 to clear itself of the charges.

A highway accident involving a large commercial truck has left a fully prostheticized man dead, his body torn apart from the impact. Togusa is summoned by Aramaki to delve deeper into the matter as the dead man had recently tried to blackmail the Energy Ministry.

The dead man's name was Kanji Kotan and he had recently arrived to Niihama by way of Tōkyō. Due to the rest of Section 9 guarding the Prime Minister ("INDUCTANCE"), Aramaki can only send Togusa, with a Tachikoma as protection, to dig up what he can about the man's recent activities before he died.

Despite close scrutiny by the authorities, the Dejima refugees declare their independence. Kuze is suspected to be the mastermind behind this new resistance and Section 9 is sent to detain him.

The Major hacks into the refugee cyberbrain hub and easily locates Kuze. When the team rushes to capture him, however, they find themselves in the middle of a trap.

The city of Fukuoka is evacuated when a live nuclear bomb is found. With the Dejima Refugees targeted as the prime suspects, the government sends the Self-Defense Forces into the city.

Aramaki suspects the CIS's involvement in this latest incident is deeper then it appears. Batou is sent to gather more information from Gouda, but will he be able to hold his temper against the arrogant agent?

With the felling of Dejima Bridge by the refugees, a rumor circulates around the Cabinet that the refugees plan a mass suicide bombing using nuclear bombs. Fearing this, the Cabinet steps up the attack against the city. Meanwhile, Prime Minister Kayabuki has been secretly arrested and taken to an unknown location. Aramaki, Togusa and Proto, in trying to help the P.M. are also taken into custody and secured in her office.

With Section 9 having entered the non-communication zone and Aramaki being cut off from communication, Ishikawa and a Tachikoma make their way to Spring-8 on their own. Meanwhile, Gouda has sent an unwitting Section 4 after Section 9 to retrieve the plutonium.

As the attack on Dejima escalates, the Major catches up with Kuze. She explains the whole situation to him and he agrees to follow her. They are about to leave when both are attacked by the Self-Defense forces and in the confusion are trapped under the rubble.

Togusa rescues the Prime Minister and brings her back to her office. There, Aramaki hopes her influence will stop the launching of the ultimate weapon. Meanwhile, Batou reasons with Section 4.

Kuze and the Major come up with a plan to save the refugees, but the chances of its success are slim. Realizing this, the Tachikomas disobey the Major's orders and come up with a plan of their own. Batou has also disobeyed the Major's orders to go to the bridge and is desperately searching for her in the ruins of Dejima. Meanwhile, the Prime Minister is frustrated with being spurned by the Chief Cabinet Secretary. Determined to be remembered as more than a mere figurehead, she takes matters into her own hands.