Wayne works with the joint Mexican-American "Fusion Center” to track the sicarios responsible for the recent bloodshed. Isa ignores orders to stay in the embassy and instead pursues a lead to the Guerrero Cartel. And Lalo puts his career at risk, battling the Mexican President for control of the narco investigations.

Isa recruits her first "asset," a source with connections to the cartel, but stretches ethical boundaries in the process. A visitor from Wayne's past dredges up unpleasant and violent memories. Lalo risks his relationship with his wife to pursue a rape prosecution against children of the rich and powerful. And Bautista’s plan for the city starts to become clearer.

Wayne, Isa and Pamela undertake a dangerous mission, infiltrating a corrupt banker who could lead them to the Guerrero cartel. Lalo and Isa start to bond while working on an art exhibition, but their past conflicts re-emerge to threaten their friendship. And Bautista’s sicarios conduct a mysterious operation that ends up having terrifying consequences for the city.

Wayne, Isa and Romero work frantically to rescue the hostages. Lalo and his police force do the same, but Lalo has his own agenda. Bautista carries out a mysterious plan involving his sicarios. And Wayne and Isa eventually come a terrible realization about why Bautista invaded the city.

Lalo's left reeling from the events of the last episode. He takes Isa on a trip to his family’s estate outside of the city, which allows Isa to learn one of Lalo’s biggest secrets. Meanwhile, Wayne discovers Bautista’s weakness and uses it to lay a trap for the narco. But Bautista is also laying a trap of his own.

Isa breaks with Wayne over the recent bloodshed and engages in risky behavior, both professional and personally. Wayne visits a figure from his past, and in flashback, we learn the tragic origins of his hatred for Bautista. Bautista takes a physical and spiritual journey into the hills of Guerrero, coming to a decision that will have horrible consequences for Lalo and the entire country of Mexico.