When Mayberry's local pharmacist falls ill, his niece Ellie Walker steps in as a temporary replacement -- and creates turmoil with the town's resident hypochondriac.

Aunt Bee, accused by Andy of being a hopeless gossip, sets out to prove that the men of Mayberry are even bigger rumormongers than the women.

The men of Mayberry become infatuated with Ellen Brown (Barbara Eden), a curvaceous manicurist who sets up shop in Floyd's barbershop. But the women of Mayberry are less than enthusiastic about the situation.