Across the country, vampires have “come out of the coffin” following the invention of mass-produced synthetic blood. In Louisiana, Sookie Stack house, a waitress with telepathic abilities, falls under the spell of sexy, 173-year-old vampire Bill Compton whose thoughts she can’t read. After saving Bill from the Rat trays, a pair of ruthless “vampire drainers”, Sookie tests the limits of Bill’ s gratitude when the two are left alone in the dark. Meanwhile, Sookie’ s best friend Tara goes to work for Sam merlette at his bar and grill, while Sookie’ s roguish brother Jason finds himself in hot water when a “fang-banger” with whom he’s been intimate meets a tragic end.

After Sookie gets saved by Bill she suffers a lot of injuries and Bill tries to save her "the Vampire way". The next day her brother is released from police custody and the bodies of Sookie's attackers are found. Later that day Bill goes to visit Sookie's family and gets a not so friendly welcome.

Tara visits LaFayette seeking comfort from her woes, Sookie meets some of Bill's rowdy friends and saves them from harm from a human among them, and, Sookie and Hugo visit the Church of the Fellowship of the Sun.

One of the barmaids from Merlotte's is murdered and all signs point to Jason as her killer. Also evident is the fact that she had been around vampires, and Sookie knows just where to go to find out who the girl had been with. Bill introduces Sookie to Fangtasia, the biggest vampire bar in Shreveport, and Eric, the oldest vampire in Shreveport. Her search could lead her into territory she never thought she'd cover.

Bill wins over Adele's church group with his vivid recollections from the Civil War; Sam reveals his feelings to Sookie; Jason gives vampire blood another shot with the help of Lafayette, and hurts Tara in the process.

Sookie seeks refuge from her friends' and neighbors' inner voices; Jason wrestles with withdrawal symptoms; Tara's mother needs her help; Sam and Tara make a connection.

Sookie's painful childhood revelation spurs Bill into action; Tara agrees to pay for an exorcism for Lettie Mae; Jason travels to Fangtasia in search of V juice.

Sookie tries to hold herself together in the wake of another possible tragedy; Tara lashes out at Sookie and Sam; Amy charms the crowd at Merlotte's.

Bill must pay a steep price for protecting Sookie; Jason and Amy break a taboo; Tara consults with Miss Jeanette about exorcising her inner demon; Bill enlists an unlikely bodyguard.

Sam shares a secret with Sookie; Lettie Mae and Tara celebrate; Jason and Amy debate what to do with Eddie; Bill faces a harsh penalty.

Sookie and Sam investigate her most recent vision; Jason helps clean up Amy's mess; Tara becomes angry with Lettie Mae; Lafayette visits a senator.

Sookie finds a link to the string of killings in Bon Temps; Tara wants to make the most of her second chance; Jason finds a new calling; Bill tempts fate; Sam is upset by an encounter with an old acquaintance.

A shocking murder outside Merlotte's has Bon Temps reeling. Meanwhile, Sookie's relationship with Bill is tested when she learns about Jessica, and of his involvement in her uncle's death. Sam recalls a shape-shifting encounter he had with Maryann as a 17-year-old. Jason gets a sudden windfall that allows him to pay for a leadership retreat with the Fellowship of the Sun. Two adversaries find themselves sharing a mysterious dungeon and, possibly, the same fate.

Bill and Sookie travel to Dallas to carry out Eric's mission; Jason falls victim to a practical joke; Maryann throws a birthday party for Tara.

A wounded Eric plays Sookie for a sucker, to Bill’s dismay, and ends up getting inside her head. Later, Sookie and Jason bond over their recent adventures. Blaming Eggs for Tara’s bruises and bizarre behavior, Lafayette and Lettie Mae try to figure out a way to pry their kin from Maryann’s clutches. Hoyt defends his relationship with Jessica to Maxine, to no avail. Jailed by Bud along with a group of Bon Temps revelers, Sam looks for a way to escape and avoid capture by an increasingly obsessed Maryann. In Dallas, Eric and the vampires defend their recent actions to Nan Flanagan and are shocked when Godric decides to take the fall for their PR disaster.

Sookie, Bill and Jason return to a Bon Temps turned upside down by Maryann. Lured to Merlotte’s by Arlene, Sam and Andy find cold comfort in their refuge from a group of bloodthirsty revelers. Bill discovers that traditional vampire techniques don’t work on Maryann; Hoyt and Jessica try to keep a lid on Maxine’s madness; and Sookie tries to push through the darkness consuming Tara. With all hell breaking loose, Jason takes the bull by the horns to rescue Sam, at least for the moment.

With the crisis in Bon Temps careening out of control, Bill seeks out the advice of Sophie-Anne, the Vampire Queen of Louisiana, but must exercise patience before she gives him critical information. Meanwhile, Sookie and Lafayette find that protecting Tara from herself is more difficult than they anticipated; a desperate Sam turns to an unlikely source for assistance; and Jessica tests Hoyt’s allegiance to Maxine.

Sookie turns to Eric for help finding Bill; Andy urges Jason to stay the course; Sam reconnects with his past; Tara seeks refuge from her grief.

Russell Edgington, the Vampire King of Mississippi, concocts a plan to consolidate his power. Eric remembers his past; Sam tests the strength of his family bonds; Tara finds an ally in a shady vampire named Franklin Mott.

Eric plots his revenge against Russell; Sookie considers a new life without Bill; Tara discovers some surprising news about Sam; Jason finds a new calling; Lafayette turns to Jesus for help; Hoyt hopes for a future with Jessica.

Sookie nurtures Eric; Bill gets involved personally in the necromancy crisis; Pam takes the veil; Sam becomes Tommy's accomplice; Arlene and Terry look to religion to solve their problem; Jesus and Lafayette head to Mexico to harness a shaman's power; Jason convalesces.

Salome reveals her true allegiances; Sookie embraces her human side; Sam sniffs out some perps; Alcide braces for a fight.

A desperate Bill tries to ferry Warlow away from the faerie plain, but Sookie is having none of it. Meanwhile, Eric arrives at vamp camp, looking to inflict serious human damage. In Bon Temps, friends and family take emotional turns remembering a fallen neighbor. Bill feels the pull of Lilith’s sirens.

Jason feels a vampire attraction firsthand; and Bill finds that salvation isn't free. Meanwhile, Sookie considers her future with Warlow as a new crisis poses a threat to humans and vampires alike.

A band of rogue H-vamps crashes the vampire-human mixer at Bellefleur’s, with shocking results. As Sookie seeks refuge from accusations that she’s somehow to blame for the chaos in Bon Temps, the “one vampire for every human” plan moves forward. In the face of a vigilante insurrection led by redneck Vince, Bill receives aid from an unexpected source.

A trio of hostages taken in the Bellefleur’s attack looks to a familiar face as a possible liberator from the H-vamps. Sookie and Jason visit the neighboring town of Saint Alice, where a young woman’s diary offers clues to the potential fate of Bon Temps. Spurned by Lafayette, a desperate Lettie Mae turns to Willa to channel her family past. Vince whips his fellow vigilantes into a dangerous frenzy. Pam’s search for her maker leads her to a very familiar place.

Sookie hatches a dangerous plan to take down the H-Vamps, even as Vince and his armed vigilantes pose an equally serious threat. Lafayette gets high with James; Jason eyes a family future with Violet; Willa is forced to find a new place to stay; Sarah Newlin sheds her past. Pam offers Eric a compelling reason to return to Louisiana – and be the vampire he used to be.

In the aftermath of yet another bloodbath, Sam, Sookie and Jason find themselves the bearers of bad news in Bon Temps and beyond. Pam recalls the events that led her and Eric to Shreveport and Fangtasia. Bill and Jessica get nourishment from unexpected sources. Following a new lead, Sookie enlists a band of vampires and humans to track down the H-Vamps.

Exhausted from her recent travails, Sookie finds herself the unwilling host of a festive mainstreaming party in Bon Temps. In search of an elusive adversary, Eric and Pam head to Dallas and attend a gala fundraiser. Andy makes a life-changing decision; Jessica and James reach a crossroads; Bill loses himself in remembrance of human days.

Eric and Pam find a new ally in their search for a common enemy; Sookie makes a startling discovery that forces her to rethink her recent involvement with Bill; Lafayette shares a vision with Lettie Mae; Jason realizes how he really feels about Violet; Sam isn't sure what to do about Nicole.

Sookie looks for a miracle; Eric and Pam zero in on Sarah Newlin; Adilyn and Wade seek protection from Violet.

Eric mulls his options; Sookie puts her life on the line for Bill; Lettie Mae finds closure; Violet has revenge on her mind.

Bill alienates Sookie; Hoyt remembers the past; Eric faces a dilemma.

Sookie weighs a future with and without Bill. Eric and Pam struggle with their uncomfortable partnership with Mr. Gus. Sam makes a choice, while Andy comes upon an unexpected inheritance. Series Finale.