A year after rescuing Catherine Martin from the horror of Buffalo Bill’s basement, FBI Agent Clarice Starling gets an urgent assignment from Catherine’s mother, Attorney General Ruth Martin, to join the Violent Criminal Apprehension Program (VICAP) in the investigation of three serial killings.

As ViCAP finally gets the green light to raid Alastor Pharmaceuticals, Clarice punches another FBI agent in a moment of rage, then willingly turns in her badge and gun. Also, the rest of the ViCAP team uncovers the whole truth about the River Murders, and Clarice unwittingly puts herself in mortal danger.

On the heels of ViCAP uncovering the secrets behind the River Murders case, Clarice is imprisoned in an abandoned animal testing facility where she finds trafficked women being held captive. As Clarice attempts to break from her captors and rescue all the women, ViCAP and Ardelia team up to locate her.