Catherine Martin escapes to Carneys Point, N.J., to confront Buffalo Bill’s mother, Lila Gumb. When Ruth recruits Krendler and ViCAP to track her down, Clarice volunteers to be the one to find Catherine before she commits a vile act and becomes a monster herself. Also, Julia continues to assist the ViCAP team’s investigation despite the huge personal risk.

Clarice zeroes in on the entity behind the River Murders, Alastor Pharmaceuticals. When Julia informs ViCAP of the impending sale of the company, ViCAP rushes to Alastor to prevent the purging of any incriminating evidence. Also, Clarice questions Alastor CEO Nils Hagen, who quickly changes the subject to Clarice’s relationship with his son, Tyson.

As ViCAP finally gets the green light to raid Alastor Pharmaceuticals, Clarice punches another FBI agent in a moment of rage, then willingly turns in her badge and gun. Also, the rest of the ViCAP team uncovers the whole truth about the River Murders, and Clarice unwittingly puts herself in mortal danger.

On the heels of ViCAP uncovering the secrets behind the River Murders case, Clarice is imprisoned in an abandoned animal testing facility where she finds trafficked women being held captive. As Clarice attempts to break from her captors and rescue all the women, ViCAP and Ardelia team up to locate her.