A year after rescuing Catherine Martin from the horror of Buffalo Bill’s basement, FBI Agent Clarice Starling gets an urgent assignment from Catherine’s mother, Attorney General Ruth Martin, to join the Violent Criminal Apprehension Program (VICAP) in the investigation of three serial killings.

Clarice Starling and the VICAP team are deployed to Tennessee where the FBI is laying siege against a fringe militia group called “The Statesmen,”

In order to prove to Krendler and the VICAP team that she is fit for duty, Clarice must find the psychological key that will unlock a confession from the suspect in the three river murders.

Sidelined because of her harrowing ordeal with Marilyn Felker, Clarice goes to Ruth Martin to be reinstated and gets roped into having dinner at the Martin residence.

After ViCAP links the River Murders to a pharmaceutical company, Clarice seeks help from Julia Lawson, the corporate accountant for the company, who refuses to work with the FBI, and with Clarice specifically. Also, Catherine goes outside for the first time since her rescue from Buffalo Bill, and Ardelia and Agent Garrett connect with a lawyer they hope will take on the Black Coalition's case against the FBI.

Catherine Martin escapes to Carneys Point, N.J., to confront Buffalo Bill’s mother, Lila Gumb. When Ruth recruits Krendler and ViCAP to track her down, Clarice volunteers to be the one to find Catherine before she commits a vile act and becomes a monster herself. Also, Julia continues to assist the ViCAP team’s investigation despite the huge personal risk.

Clarice zeroes in on the entity behind the River Murders, Alastor Pharmaceuticals. When Julia informs ViCAP of the impending sale of the company, ViCAP rushes to Alastor to prevent the purging of any incriminating evidence. Also, Clarice questions Alastor CEO Nils Hagen, who quickly changes the subject to Clarice’s relationship with his son, Tyson.

As ViCAP finally gets the green light to raid Alastor Pharmaceuticals, Clarice punches another FBI agent in a moment of rage, then willingly turns in her badge and gun. Also, the rest of the ViCAP team uncovers the whole truth about the River Murders, and Clarice unwittingly puts herself in mortal danger.

On the heels of ViCAP uncovering the secrets behind the River Murders case, Clarice is imprisoned in an abandoned animal testing facility where she finds trafficked women being held captive. As Clarice attempts to break from her captors and rescue all the women, ViCAP and Ardelia team up to locate her.