Sally begins her job as Bobut's new nanny, to Bobut's amusement. Adam and Snizzy reanimate a dead frog. . .which then mutates and begins terrorizing the town. Bobut goes on a playdate with Doug's boss's son, and winds up using mind-control on the boss to get Doug an undeserved promotion. Doug happily accepts the promotion at first, but then the responsibility becomes too much to bear.

Doug has contracted the flu. Adam tries desperately to get sick to avoid having to wrestle at school, but Doug's mutating, talking germs get everyone else in the family sick. Sally, who has become Bobut's prisoner more than his nanny, is unhappy with the way her life is going, so Bobut tries to find her true love – by using mind-control and holding a man captive.

Heather gets a zit, so Snizzy conjoures up some anti-zit cream. Cookie gets a job at Doug's company and becomes vice-president after one day at work. But problems arise when a efficient robot that she's brought to work is a threat to all of her co-workers jobs.

Sally puts Bobut on a no-pudding diet and his usual antics ensue. The family gets hyped up when Spit's pet, Varch, a Harnazian Funazz, comes to live with the family. Varch takes an instant liking to Heather, who can't stand him. To make matters worse, Heather's new boyfriend, Ethan, comes to visit, and Varch welcomes him by eating the boy. But Heather feels bad when she finds Varch asleep in her closet and throws a shoe at him – but he doesn't wake up. Heather thinks Varch is dead, but doesn't realize his breed sheds their exoskin.

Two of The Elders of the Neurtron Galactic Federation, the supreme beings who rule over the destinies of the alien Brody family members, pay a visit to see how future leader Bobut is being raised. Bobut quickly becomes disillusioned with High Elder Prissy's training methods (and the heavy crown he has to wear), so it's up to Doug to prove to Sissy that Bobut is being properly educated. Meanwhile, Heather goes out of her way to impress a clique of popular girls by having Spit gross them out.

While Doug makes plans to have a ""Brody Family Vacation,"" Sally daydreams about spending her time off having romantic dinners with a handsome exotic man. In preparation, Sally offers to have Bobut's passport photo taken by a happy clown. . .but the clown's happiness turns to despair when Bobut attacks him. Meanwhile, Spit invents a fake alien holiday as an excuse to get out of his schoolwork. But when little Bobut overhears Spit telling his siblings about it, Bobut expects a Tweeznax celebration.