Columbian Enrique Cuellar (Ricardo Montalban) has inherited land which was leased and used by Judge Garth. The Judge wants to renew the lease or buy the land outright. He minimizes its importance to his operations even though it contains a pass needed to drive his cattle herd between its seasonal ranges. Enrique discovers this deception and demands a large amount of money for the land. The Judge decides to drive his cattle through the land before Enrique can get a legal restraining order and in turn Enrique begins erecting a barbed wire fence to block the passage. A violent confrontation seems inevitable but is prevented by an unpredictable event involving Betsy Garth.

A new school teacher, Arthur Lilley (George C. Scott), and his uppity wife (Anne Meacham) come to Medicine Bow. Arthur is a well-educated man and his wife believes the job beneath him but Arthur sees himself as a coward, thinking he was responsible for the deaths of several students in a fire at his former school in Vermont. When two murderers escape from prison and take as hostages the teacher, his wife and the school children including Betsy Garth, Arthur's mettle meets the supreme test.

The new owner of Shiloh quickly finds his hotheaded grandson accused of cattle rustling. He learns his neighbor is the widow of a friend who died with him. The sullied family name reduces their finance options putting Shiloh in jeopardy.

A white girl is caught with her adoptive Arapaho parents stealing Shiloh cattle. She stays at Shiloh while the authorities try to find her white parents. She wants to return to the Arapaho but is forced to learn to live in the white world.

Trampas leads a two man posse to capture the brother-in-law of a friend in jail who is innocent when the Sheriff is injured. They encounter others who hinder their progress and an unhappy couple. But the big problem is Trampas' partner.

On the range Trampas spots a girl (Valora Noland) riding a pinto whom he has seen before but whom no one believes exists including the Virginian. Trampas rides after her but she rides off refusing to talk to him. In town he sees her again with her mother, Miriam Harley (Vivi Janiss), learns her name is Amanda, and that her parents have bought a local farm. He tries to get her to go a dance but she refuses. As the Harley's leave town they are watched by a man, Richard Pierce (Warren Stevens), who has just arrived at the hotel. Pierce learns where the Harleys live and later visits and talks with Amanda but rides off when her father, Frederick (R. G. Amstrong) arrives. In town, Pierce tries to get the stationmaster to arrange to stop a train so it can drop off some horses and is overheard by Sheriff Mark Abbott. He also briefly talks with another man who arrives on the train, Bert Robinson (Sandy Kenyon). The Sheriff returns to the jail where Marshall John Howard (Ken Mayer) is waiting a