Former British soldier Gavin Heath (Leo Genn) strikes it rich and returns to Medicine Bow where he had previously lived. Heath is attacked by an apparently rabid dog. Thinking he may only have 30 days to live, Heath is forced to confront his cowardly past.

Steve Hill is asked to go under cover by a US Marshall (Don Collier) by renewing his relationship with a former girlfriend, Jane Carlisle (Ruta Lee),who is a new dance hall girl at the Medicine Bow saloon. The Marshall suspects Jane is part of a notorious robbery gang out to steal gold destined to pay for Indian land. Steve reluctantly agrees to do so and to gain the gang's confidence begins to act irresponsibly much to the chagrin of the Virginian and Shiloh hands who are unaware of his task. In the end Steve must face the robbery gang and its ruthless leader (Mark Richman) and his fate is in the hands of Jane.

Ryker invites the man who raised him to come to Medicine Bow after being released from 10 years in prison. When Ryker finds Abe has invited his family to join him, he knows there are problems as Shiloh makes a record sized cattle shipment.

The Virginian makes the acquaintance of a young man, Mark Shannon (Richard Beymer), who along with his sister (Diana Lynn) and her love interest, trail boss Jack Slauson (Myron Healey), is taking a cattle herd to the army. When near Medicine Bow it is learned the Shannon herd could be carrying Spanish fever. Those cattle are largely immune but the local cattle are not. The local ranchers, with the Virginian acting as their delegate, try to get the herd to bypass the Medicine Bow area. By taking another, but more direct, route, the herd would avoid infecting the local cattle. However,there would be substantial losses to the Shannon herd because of a drought affecting the other route. Mark refuses and this leads to a showdown not only with the Virginian and Medicine Bow ranchers but also with Slauson.

In Cobb's Run, Kansas, while waiting for the Virginian, Randy Benton is framed for a $50,000 payroll robbery. His defence, that the legendary but aging town marshall, Floyd Buckman (Ford Rainey), had inadvertently allowed the robbers into the bank, is scoffed at by the locals. As a result, Randy is sentenced to be hanged. The Virginian tries to track down the the real robbers to prove Randy's innocence and in desperation even breaks Randy out of jail. In the end however, Randy's salvation is in the hands of the legendary lawman.