After a new memory, Andrea finds it hard to believe what his memory seems to be suggesting to him, and he asks Enrico to discontinue treatment. Even on the ward, the situation is far from quiet. In addition to Rita, a young girl who refuses chemotherapy, Andrea and his team have to deal with the case of a patient they know all too well.

Doc sees some of the certainties he had about his past collapsing and, to shed light on what happened, he also drags Giulia into his search, who is challenged by the idea that her relationship with Andrea was based on a lie. Angelo, a patient whose condition forces Martina to prove herself, has problems with his past, too.

The therapy sessions with Enrico seem to have side effects on Doc, who sees his ability to take care of patients called into question. Agnese seizes the opportunity to crush his research into the past, while Giulia is convinced that Andrea should not give up, despite his problems: in fact, his brother Fabio is admitted to the ward.

Doc finally knows how to track down the woman he is looking for, but he must first find the courage to do so. Meanwhile, Ric faces the case of an undisciplined personal trainer, while Damiano must deal with the hospitalization of a model, his brother Samuele's girlfriend. This case threatens to bring up old family grudges.

The fear of discovering the secret about his past is too strong for Doc. However, this denial of the truth drives him away from the ward, much to the surprise of Giulia, who has to take care of a patient who, just like Andrea, seems to be hiding something. Meanwhile, Enrico must deal with Barbara's assaults, which may be hiding more than just infatuation.

Doc enters a competition with an AI: if he does not want to be replaced by a machine, he must find the correct diagnosis for a patient before the computer. Martina, on the other hand, is given a case that forces her to come to terms with her conscience, while Agnese is confronted with a terrible decision to protect one of Andrea's secrets.