A man who knew Kimble during one of his disguises, meets him again. He tells him that on one of his hurried, silent departures from a town, he left behind evidence which indicated he was dead and an innocent man is being held for his murder.

Kimble arrives in a small town where women are being murdered by an unknown serial killer and a vigilante mob mistakes Kimble (a stranger in town) of being the killer. Kimble hides out with a young woman with learning difficulties named Joanne Mercer, a 'moon child' befriends Kimble and hides him in the basement of her house which is connected by a underground tunnel to a closed-down textile factory where the real killer is hiding out.

While working as a truck driver for a small freight company, Kimble discovers that his angry and bitter boss, Gus Hendrick, is being blackmailed by Lucia Mayfield, the wife of his late business partner, into paying her bills and for child support since Mr. Mayfield was killed a year earlier in a driving accident. But Kimble later learns that with Hendrick strapped for money, and Lucia merely squandering the blackmail money for her own selfish purposes, Hendrick plans to hijack one of his own trucks to collect an insurance settlement.

A woman calls the police after she recognizes Kimble's picture on a TV quiz show and in the ensuing manhunt, Kimble hides out in a home for the blind. Kimble becomes acquainted with some of the residents, including the attractive Claire Whittaker whom he assists, as well as Pete Haskell whom Kimble discovers is not really blind and was actually temporarily blinding in a school bus accident months earlier which Pete blames himself since he was driving drunk at the time. But one of the residents is a certain Dan Brady, a veteran lawman whom was blinded in the line of duty and has now been put out to pasture. Brady remains bitter for having lost his position as the town's sheriff to the younger, more educated, but less experienced, Barney Vilattic. When Brady suspects Kimble's true identity, he sees an opportunity to capture the fugitive to reclaim his former job.

While working as a ranch hand on a California citrus farm, the owner, Leland Hagerman, suddenly dies in an accident and the man's racist and sadistic son, Blaine, arrives to stake his claim to the place and sees everyone as expendable, including Kimble whom must find a way to quietly slip away with the help of the Hispanic workers before Blaine stumbles upon his true identity.

While dating a local woman named Laurel Harper, Kimble breaks off their romantic affair and she angrily storms out of the bar they are in and into the night. The next morning, Laurel is found on an abandoned road unconscious and badly beaten. While she is taken to a hospital for treatment, Laurel's paranoid and suspicious sister, Sheila, convinces the police to hold Kimble for questioning.

Kimble's sister Donna summons him home with a possible break in the case: a letter from James Eckhardt, a former U.S. Army captain whom also saw the one-armed man fleeing from the Kimble's house on the night of Helen's murder. Kimble meets with Eckhardt who agrees to help the fugitive out. Eckhardt's story seems strong enough to clear Kimble. But unknown to either men, another witness comes forward: a convict in prison for drug dealing, who reveals that he used to sell heroin to Eckhart for a Korean War battle wound and that Eckhardt was on his way to see him that night to buy some drugs, which is more than enough for Gerard to discredit Eckhardt's testimony.

In the small town of Drover City, Montana, Kimble stumbles onto the annual ""vigilante roundup,"" a carnival of sorts where locals ""hunt"" down anybody not wearing Western cowboy clothing. After being ""lassoed"" literally, Kimble is held ""prisoner"" in the local school cafeteria where the dance hall is. Meanwhile, Gerard arrives in the area after hearing reports of Kimble's spotting, has the state police set up roadblocks outside the town, and then enters looking for the fugitive. Gerard shows Kimble's mug shot to Charley Judd, the town marshal whom recognizes Kimble. But Charley mistakenly thinks there's a reward on Kimble (and Charley wants to keep all the money for himself). So, he sends Gerard away on a false lead and has his girlfriend, Laura, transport Kimble to the real jail at the police station. There, Kimble must persuade Laura to let him go by telling her that Charley is in it for his own selfish reasons, just as Gerard figures out that Charley has sent him on a wild-goose chase

Kimble arrives in the factory town of Hempstead Mills, West Virginia to assist Andrew McCallister, his longtime mentor whom is dying from lung cancer which he is confined to a wheelchair. McCallister's vigorous anti-smog campaign has earned him a reputation as a local crackpot. But the old man plans to go out with a bang; by having a bomb hidden in a package where he has Kimble deliver to the local factory. But when McCallister discovers that a group of school children will be inside the factory during a school tour at the time of the explosion, he dispatches Kimble to evacuate the building and deactivate the bomb before time runs out.