While working as a chauffeur in Denver, Colorado, Kimble reluntantly covers for teenager Lauire Ryder after she dents her father's car. But Kimble flees after discovering that Laurie was involved in a hit-and-run. After learning Kimble's idenity, Laurie's father, Dr. Mark Ryder, summons Gerard (along with the entire Kimble file) to Denver where he introduces Gerard to the 2130, a computer that can help capture the fugitive by determining a pattern to his travels. As the 2130 makes progress, Kimble's new travels all over the country end with one close escape after another with the police.

While working as a veterinarian assistant in a rural town in Utah, Kimble becomes aquainted with Ruth Simmons, an unwed teenage mother whom has a sickly infant. But her father, Joshua, is a Christian Scientist whose religion prohibits the use of medicine for any ailment. Kimble brings over antibiotics, but Joshua destroys the drugs. After determing that the baby is anemic, Kimble secretly arranges for a blood transfusion. Meanwhile, after stumbling upon Kimble's true idenity, a would-be deputy, named Pete, searches for the fugivtive with the aid of his two bloodhound dogs.