Richard Kimble returns home when he learns his wife's family is in financial trouble. The complications are that his mother-in-law hates him, his sister-in-law loves him, and his father-in-law is being questioned by the police.

While working as a hospital orderly, Kimble is recognized by Victor Leonetti and his wife Anne whom hold Kimble responsible for the death of their daughter. Kimble tries to flee, but gets shot and is forced to undergo surgery for the gunshot wounds. But when Victor learns that Kimble was trying to contact a specialist at the time of the girl's death, he tries to make amends by confessing to Gerard, whom arrives at the hospital, that he was the one who murdered Helen Kimble.

Kimble reluctantly becomes involved with Stella Savano, the sister of George Savano, a mobster who runs the trucking company where Kimble works. Stella is an emotionally disturbed women with a dangerous attraction to Johnny, the adopted eight-year-old son of Jesse Stangel, Kimble's co-worker. Kimble learns that Stella is actually Johnny's mother. But Stella becomes so delusional that she thinks that Kimble is Johnny's father.

Kimble visits an enclosed plaza in the heart of the city. Due to a misunderstanding, on-site security mistakes him for someone else and gives chase. Thinking they are on to him, Richard tries to jump a fence but is caught by a guard, and has to punch him out to get away. A lady working at a camera store lets him stay at her place (in the plaza), while he rests and heals. To complicate things more, Kimble's earlier visit to the video store was caught on video tape, and someone who sees the tape recognizes him. Kimble's visit also coincides with an accidental shooting inside of a storage room, so the police are at the plaza, investigating.

This was the series finale. In the first part, the one-armed man whom Kimble has been pursuing has been arrested for a minor crime. Lt. Gerard tries to use this to lure Kimble out into the open. A woman who knows Kimble tries to help him. Kimble tries to see if this man is the one he is looking for but someone wires a bail bondsman some money to bail him out. KImble then visits the bail bondsman but finds him dead. He then goes through his papers and is shocked to see who sent the money. He then goes to see this person but Gerard catches and takes him in. As the one-armed man hops on a train, Kimble and Gerard are making their way back.

In the continuation of this story Kimble and Gerard are on a train for his hometown in Indiana. And Kimble then reveals that the person who sent the bail money is his brother-in-law Leonard Taft. Kimble doesn't think it was him but someone from his hometown did send the money and used his brother-in-law's name. The one armed-man calls the Tafts demanding that they meet with him, someone does go to the meeting but it's not Leonard Taft but the one-armed man assumes that he is, and says that he remebers him. Obviously this was the man who sent the money and the one-armed man is demanding more money which he doesn't have. Kimble and Gerard arrive at the Taft residence and talk to Len, who tells them that someone called claiming the same thing and arranged a meeting, Kimble ans Gerard arrive at the place and find some bullets. But for Gerard there is nothing more that can be done; they then go back to the Taft house so that Kimble can say good-bye to his sister, and it's at that moment tha