While traveling through an small Oklahoma town, Kimble is arrested, not because the police recognize him, but because they've mistaken him for Leonard Hull, a former numbers runner about to testify against a big-time racketeer, whom has run away from a witness relocation program in that very town. Kimble is taken to a motel where Leonard's wife, Mavis, knows he's not Leonard in which Kimble asks for her help to get away from the police, and a local hit man pursuing them.

While working as a veterinarian assistant in a rural town in Utah, Kimble becomes aquainted with Ruth Simmons, an unwed teenage mother whom has a sickly infant. But her father, Joshua, is a Christian Scientist whose religion prohibits the use of medicine for any ailment. Kimble brings over antibiotics, but Joshua destroys the drugs. After determing that the baby is anemic, Kimble secretly arranges for a blood transfusion. Meanwhile, after stumbling upon Kimble's true idenity, a would-be deputy, named Pete, searches for the fugivtive with the aid of his two bloodhound dogs.