Life for former United Nations investigator Gerry Lane and his family seems content. Suddenly, the world is plagued by a mysterious infection turning whole human populations into rampaging mindless zombies. After barely escaping the chaos, Lane is persuaded to go on a mission to investigate this disease. What follows is a perilous trek around the world where Lane must brave horrific dangers and long odds to find answers before human civilization falls.

Months after a zombie plague has wiped out 90 percent of the American population, a small group of survivors fight their way cross-country to a rumored refuge on the island of Catalina.

A young woman (Tansy Parkinson) who possesses the supernatural powers and visions of an upcoming apocalypse is aided by a retired bounty hunter who must protect her from those who wish to use her abilities for evil.