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Lee Myung-hyun and his disease control task force investigate a mutant virus that has a 100% fatality rate and kills the infected within three days. Not only must they find an antidote, they must also stop the epidemic from spreading and killing all of mankind.

The film centers around a Malaysian pharmaceutical company using a new virus to generate an epidemic. A secret organization, known as "The Leaker", discloses this information. After the suicide of the pharmaceutical company's son and a local reporter, the wife of the pharmaceutical company's owner leaves for Hong Kong. A Malaysian police chief , Hong Kong police officer, and journalist work together to locate her whereabouts.

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