A family are haunted by a Hebi Onna, a fabled demonic undead Snake Woman.

Under a powerful Mayan curse, snakes are hatched inside a young woman, slowly devouring her from within. Her only chance for survival is a powerful shaman who lives across the border. With only hours to live, she jumps on a train headed for Los Angeles. Unfortunately for the passengers aboard, they are now trapped, soon to be victims of these flesh-eating vipers.

Everyone abuses and humiliates a downtrodden orphan until he befriends an old man, who turns out to be the last master of the snake fist fighting style. Jackie becomes the old man's student and finds himself in battle with the master of the eagle's claw style, who has vowed to destroy the snake fist clan.

A young peasant boy who is bullied by local noblemen seeks to learn drunken boxing from the head of a local martial arts school. When the boy beats up his previous tormentors, the nobles patriarch challenges the boys teacher, the drunken master, who defeats the lot of them. Embarrased, the nobles retain two hired snake style killers. They kill everyone except the peasant boy.