Karen Cooper wants to domineer her family and believes she's its pillar. In fact she does everything wrong. Thus she messes up all their lives and futures, rather then help her loved-ones.

In 1918, when New York City hired its first scientifically trained medical examiner Charles Norris. Over the course of a decade and a half, Norris and his extraordinarily driven and talented chief toxicologist, Alexander Gettler, would turn forensic chemistry into a formidable science, sending many a murderer to the electric chair and setting the standards that the rest of the country would ultimately adopt.

Graham Young is a teenage misfit living in suburban London in the 1960s. He hates his stepmother but loves chemistry, and the two impulses unite in a wicked plot to slowly poison her. After she dies, he's found guilty and sent to a psychiatric hospital, where an idealistic doctor thinks he can be cured.